Strategies and methodologies for the construction of spiro-γ-lactams: an update

被引：35

作者：

Alves, Americo J. S. ^{[1
,2
]}

Alves, Nuno G. ^{[1
,2
]}

Soares, Maria I. L. ^{[1
,2
]}

Melo, Teresa M. V. D. ^{[1
,2
]}

机构：

[1] Univ Coimbra, Coimbra Chem Ctr, P-3004535 Coimbra, Portugal

[2] Univ Coimbra, Dept Chem, P-3004535 Coimbra, Portugal

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 13期

关键词：

OXIDATIVE IPSO-ANNULATION; ONE-POT; ENANTIOSELECTIVE SYNTHESIS; AMIDE ALLYLATION; STEREOSELECTIVE-SYNTHESIS; ACTIVATED ALKYNES; CASCADE REACTION; CYCLIZATION; ACCESS; OXINDOLES;

D O I：

10.1039/d0qo01564d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Spiro-gamma-lactams (spiropyrrolidin-2-ones) are a class of spirocyclic compounds that are present in a wide range of synthetic bioactive and naturally occurring molecules. The increasing attention to spirocyclic lactams in drug discovery has been accompanied by a growing interest in these compounds from a synthetic point of view, namely as synthetic building blocks in organic chemistry, due to their inherent rigidity and complexity. Herein, an insight into the most relevant advances in the synthesis of the spiro-gamma-lactam scaffold since 2015 is provided, addressing issues such as scope, efficiency, selectivity and mechanistic insights.

引用

页码：3543 / 3593

页数：51

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