Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease - Relationship to severity of dementia and apolipoprotein E genotype

被引:473
作者
Craft, S
Peskind, E
Schwartz, MW
Schellenberg, GD
Raskind, M
Porte, D
机构
[1] VA Puget Sound Hlth Care Syst, GRECC 182B, Seattle, WA 98108 USA
[2] VA Puget Sound Hlth Care Syst, Mental Hlth Serv, Seattle, WA 98108 USA
[3] VA Puget Sound Hlth Care Syst, Dept Med, Seattle, WA 98108 USA
[4] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
[5] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA
[6] Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA
[7] Univ Washington, Sch Med, Dept Neurol, Seattle, WA 98195 USA
关键词
D O I
10.1212/WNL.50.1.164
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Patients with Alzheimer's disease (AD) have elevations of fasting plasma insulin that are hypothesized to be associated with disrupted brain insulin metabolism. We examined paired fasted plasma and CSF insulin levels in 25 patients with AD and 14 healthy age-matched adults and determined whether insulin levels were related to severity of dementia and apolipoprotein E-epsilon 4 homozygosity, a known genetic risk factor for AD, The AD patients had lower CSF insulin, higher plasma insulin, and a reduced CSF-to-plasma insulin ratio when compared with healthy adults, The differences were greater for patients with more advanced AD, Patients who were not apolipoprotein E-epsilon 4 homozygotes had higher plasma insulin levels and reduced CSF-to-plasma ratios, whereas epsilon 4 homozygotes with AD had normal values. Both plasma and CSF insulin levels are abnormal in AD, and there are metabolic differences among apolipoprotein E genotypes.
引用
收藏
页码:164 / 168
页数:5
相关论文
共 26 条
[1]   INSULIN AND INSULIN-LIKE GROWTH-FACTOR RECEPTORS IN THE NERVOUS-SYSTEM [J].
ADAMO, M ;
RAIZADA, MK ;
LEROITH, D .
MOLECULAR NEUROBIOLOGY, 1989, 3 (1-2) :71-100
[2]   SATURABLE TRANSPORT OF INSULIN FROM PLASMA INTO THE CENTRAL-NERVOUS-SYSTEM OF DOGS IN-VIVO - A MECHANISM FOR REGULATED INSULIN DELIVERY TO THE BRAIN [J].
BAURA, GD ;
FOSTER, DM ;
PORTE, D ;
KAHN, SE ;
BERGMAN, RN ;
COBELLI, C ;
SCHWARTZ, MW .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (04) :1824-1830
[3]   Memory improvement following induced hyperinsulinemia in Alzheimer's disease [J].
Craft, S ;
Newcomer, J ;
Kanne, S ;
DagogoJack, S ;
Cryer, P ;
Sheline, Y ;
Luby, J ;
DagogoJack, A ;
Alderson, A .
NEUROBIOLOGY OF AGING, 1996, 17 (01) :123-130
[4]  
CRAFT S, 1993, BEHAV NEUROSCI, V107, P926
[5]  
Craft S., 1996, Society for Neuroscience Abstracts, V22, P1177
[6]   GENOTYPING AND SEQUENCE-ANALYSIS OF APOLIPOPROTEIN-E ISOFORMS [J].
EMI, M ;
WU, LL ;
ROBERTSON, MA ;
MYERS, RL ;
HEGELE, RA ;
WILLIAMS, RR ;
WHITE, R ;
LALOUEL, JM .
GENOMICS, 1988, 3 (04) :373-379
[7]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[8]  
Frolich L, 1996, NEUROBIOL AGING, V17, ps184
[9]  
HIXSON JE, 1990, J LIPID RES, V31, P545
[10]   CENTRAL-NERVOUS-SYSTEM AND PERIPHERAL ABNORMALITIES - CLUES TO THE UNDERSTANDING OF OBESITY AND NIDDM [J].
JEANRENAUD, B .
DIABETOLOGIA, 1994, 37 :S169-S178