Characterization of biodegradable and cytocompatible nano-hydroxyapatite/polycaprolactone porous scaffolds in degradation in vitro

被引：93

作者：

Wang, Yuanyuan ^{[1
]}

Liu, Li ^{[1
]}

Guo, Shengrong ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

来源：

POLYMER DEGRADATION AND STABILITY | 2010年 / 95卷 / 02期

关键词：

Porous scaffold; Polycaprolactone; Nano-hydroxyapatite; Degradation; Bone tissue engineering; COMPOSITE SCAFFOLDS; MECHANICAL-PROPERTIES; OSTEOBLAST ADHESION; NANOPHASE CERAMICS; BONE-FORMATION; PCL SCAFFOLDS; TISSUE; FABRICATION; POLYMER; POLY(EPSILON-CAPROLACTONE);

D O I：

10.1016/j.polymdegradstab.2009.11.023

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Porous nano-hydroxyapatite/polycaprolactone (nHA/PCL) scaffolds with different composition ratios of nHA/PCL were fabricated via a melt-molding/porogen leaching technique. All scaffolds were characterized before and after degradation in vitro for six months. The original scaffolds had high porosity at around 70% and showed decreasing compressive modulus (from 24.48 to 2.69 MPa for hydrated scaffolds) with the introduction of nHA. It was noted that the scaffolds could retain relatively stable architecture and mechanical properties for at least six months, although some slight changes happened with the nHA/PCL scaffolds in the mass, the nHA content, the PCL molecular weight and the crystallinity. Moreover, during the 7 days culture of bone marrow stromal cells (BMSCs) on scaffolds, the cell adhesion and proliferation of BMSCs were presented well on both the surface and the cross-section of the scaffolds. All of these results suggested the nHA/PCL scaffolds to be promising in bone tissue engineering. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：207 / 213

页数：7