Hypertensive disorders of pregnancy and risks of adverse pregnancy outcomes: a retrospective cohort study of 2368 patients

被引：13

作者：

Li, Xun ^{[1
,2
]}

Zhang, Weishe ^{[1
,2
]}

Lin, Jianhua ^{[3
]}

Liu, Huai ^{[4
]}

Yang, Zujing ^{[5
]}

Teng, Yincheng ^{[6
]}

Huang, Jingrui ^{[1
,2
]}

Peng, Qiaozhen ^{[1
,2
]}

Lin, Xinxiu ^{[1
,2
]}

Zhang, Jiejie ^{[1
,2
]}

Xie, Liangqun ^{[1
,2
]}

Xie, Yingming ^{[1
,2
]}

Li, Yuanqiu ^{[1
,2
]}

Luo, Jiefeng ^{[1
,2
]}

Duan, Weifang ^{[1
,2
]}

Chen, Jingfei ^{[1
,2
]}

Duan, Si ^{[1
,2
]}

机构：

[1] Xiangya Hosp Cent South Univ, Dept Obstet, 87 Xiangya Rd, Changsha 410008, Peoples R China

[2] Hunan Engn Res Ctr Early Life Dev & Dis Prevent, 87 Xiangya Rd, Changsha 410008, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Obstet & Gynecol, 145 Shandong Zhonglu, Shanghai 20001, Peoples R China

[4] Jiangxi Maternal & Child Hlth Hosp, Dept Obstet, 318 BayiDadao, Nanchang 330006, Jiangxi, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Dept Obstet, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China

[6] Shanghai Sixth Peoples Hosp, Dept Obstet & Gynecol, 600 Yishan Rd, Shanghai 200233, Peoples R China

来源：

JOURNAL OF HUMAN HYPERTENSION | 2021年 / 35卷 / 01期

基金：

中国博士后科学基金;

关键词：

GESTATIONAL HYPERTENSION; GROWTH RESTRICTION; EARLY-ONSET; PREECLAMPSIA; EPIDEMIOLOGY; PATHOGENESIS; HELLP;

D O I：

10.1038/s41371-020-0312-x

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Hypertensive disorders of pregnancy (HDP) comprise a group of hypertension-related diseases and represent the most common medical disorders in pregnancy. The aim of this study was to investigate the risks of adverse pregnancy outcomes in patients with different types of HDP, including gestational hypertension, chronic hypertension, preeclampsia (PE, early or late onset), PE superimposed on chronic hypertension (superimposed PE), eclampsia, and HELLP syndrome. Data from a multicenter retrospective patient cohort in China were analyzed. Seventeen adverse maternal or perinatal outcomes were evaluated. Logistic regression was used to estimate the risk of adverse outcomes for each HDP subgroups, using the gestational hypertension group as the reference. The final analysis included 2368 patients with HDP. Of these, 39.9% of patients reported at least one adverse pregnancy outcome. Patients with early onset PE had the highest risk for having both adverse maternal and perinatal outcomes (OR = 7.28, 95% CI: 2.68, 19.79). The risk of perinatal death significantly increased in HELLP syndrome, superimposed PE, and early onset PE, (OR = 13.81, 6.32, and 4.84, respectively, p < 0.05) groups. This study highlights that among patients with HDP, those with early onset PE had the highest risk for having both adverse maternal and perinatal outcomes, and patients with HELLP syndrome had the highest risk for perinatal death.

引用

页码：65 / 73

页数：9

共 35 条

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