Recent advances of m6A methylation modification in esophageal squamous cell carcinoma

被引：22

作者：

Zhang, Xiaoqing ^{[1
]}

Lu, Ning ^{[1
]}

Wang, Li ^{[2
]}

Wang, Yixuan ^{[1
]}

Li, Minna ^{[1
]}

Zhou, Ying ^{[3
]}

Cui, Manli ^{[1
]}

Zhang, Mingxin ^{[1
,3
]}

Zhang, Lingmin ^{[4
]}

机构：

[1] Xian Med Univ, Dept Gastroenterol, Affiliated Hosp 1, 48 Feng Hao West Rd, Xian 710077, Shaanxi, Peoples R China

[2] Xian Med Univ, Dept Sci Res, Affiliated Hosp, Xian, Shaanxi, Peoples R China

[3] Shaanxi Univ Tradit Chinese Med, Xianyang 712046, Shaanxi, Peoples R China

[4] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Anesthesiol, 277 Yanta West Rd, Xian 710061, Peoples R China

来源：

CANCER CELL INTERNATIONAL | 2021年 / 21卷 / 01期

关键词：

N6-methyladenosine; Methylation; Esophageal squamous cell carcinoma; MESSENGER-RNA METHYLATION; STEM-LIKE CELLS; N-6-METHYLADENOSINE M(6)A; CANCER; EXPRESSION; M6A; TRANSLATION; DEMETHYLASE; REGULATORS; PROTEINS;

D O I：

10.1186/s12935-021-02132-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In recent years, with the development of RNA sequencing technology and bioinformatics methods, the epigenetic modification of RNA based on N-6-methyladenosine (m(6)A) has gradually become a research hotspot in the field of bioscience. m(6)A is the most abundant internal modification in eukaryotic messenger RNAs (mRNAs). m(6)A methylation modification can dynamically and reversibly regulate RNA transport, localization, translation and degradation through the interaction of methyltransferase, demethylase and reading protein. m(6)A methylation can regulate the expression of proto-oncogenes and tumor suppressor genes at the epigenetic modification level to affect tumor occurrence and metastasis. The morbidity and mortality of esophageal cancer (EC) are still high worldwide. Esophageal squamous cell carcinoma (ESCC) is the most common tissue subtype of EC. This article reviews the related concepts, biological functions and recent advances of m(6)A methylation in ESCC, and looks forward to the prospect of m(6)A methylation as a new diagnostic biomarker and potential therapeutic target for ESCC.

引用

页数：9

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