Induction of cytochrome P4502B: Role of regulatory elements and nuclear receptors

被引：19
作者：
Pustylnyak, V. O. [1 ]
Gulyaeva, L. F. [1 ]
Lyakhovich, V. V. [1 ]
机构：
[1] Russian Acad Med Sci, Siberian Div, Inst Mol Biol & Biophys, Novosibirsk 630117, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2007年 / 72卷 / 06期
关键词：
CYP2B; phenobarbital; induction; nuclear receptors; CAR;
D O I：
10.1134/S000629790706003X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cytochrome P450 of the 2B subfamily is easily induced by many xenobiotics. In spite of intensive investigations, the molecular mechanisms of regulation of the CYP2B genes are not clear. The nuclear receptor CAR is shown to play a crucial role in the activation of CYP2B genes by xenobiotics, but many problems of CAR activation in different animal species and humans remain unsolved. This review focuses on signaling pathways involved in the control of CYP2B gene expression in mammals.
引用
收藏
页码：608 / 617
页数：10
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