Sortase Transpeptidases: Insights Into Mechanism, Substrate Specificity, and Inhibition

被引：163

作者：

Clancy, Kathleen W. ^{[1
]}

Melvin, Jeffrey A. ^{[2
]}

McCafferty, Dewey G. ^{[1
,2
]}

机构：

[1] Duke Univ, Dept Chem, Durham, NC 27706 USA

[2] Duke Univ, Dept Biochem, Durham, NC 27706 USA

来源：

BIOPOLYMERS | 2010年 / 94卷 / 04期

基金：

美国国家卫生研究院;

关键词：

sortase; virulence factor; enzyme structure; substrate specificity; transpeptidase; STAPHYLOCOCCUS-AUREUS SORTASE; PROTEIN ANCHORING TRANSPEPTIDASE; SORTING SIGNAL BINDING; SURFACE-PROTEINS; CELL-WALL; REVERSE PROTONATION; BACILLUS-ANTHRACIS; CRYSTAL-STRUCTURES; BIOFILM FORMATION; A TRANSPEPTIDASE;

D O I：

10.1002/bip.21472

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram-positive bacter a enzyme sortase. (C) 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 385-396, 2010.

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收藏

页码：385 / 396

页数：12

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