A new view of pain as a homeostatic emotion

被引:602
作者
Craig, ADB [1 ]
机构
[1] Barrow Neurol Inst, Atkinson Pain Res Lab, Phoenix, AZ 85013 USA
关键词
D O I
10.1016/S0166-2236(03)00123-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Pain is conventionally viewed as a pattern of convergent activity within the somatosensory system that represents the exteroceptive sense of touch. Accumulating functional, anatomical and imaging findings indicate that pain is generated by specific sensory channels that ascend in a central homeostatic afferent pathway. Phylogenetically new thalamocortical projections in primates provide a sensory image of the physiological condition of the body and, in addition, direct activation of limbic motor cortex. These findings indicate that the human feeling of pain is both a distinct sensation and a motivation - that is, a specific emotion that reflects homeostatic behavioral drive, similar to temperature, itch, hunger and thirst.
引用
收藏
页码:303 / 307
页数:5
相关论文
共 48 条
[1]   Trust in the brain [J].
Adolphs, R .
NATURE NEUROSCIENCE, 2002, 5 (03) :192-193
[2]  
ALTMAN J, 1984, ADV ANAT EMBRYOL CEL, V85, P1
[3]   Quantitative responses of spinothalamic lamina I neurones to graded mechanical stimulation in the cat [J].
Andrew, D ;
Craig, AD .
JOURNAL OF PHYSIOLOGY-LONDON, 2002, 545 (03) :913-931
[4]   Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch [J].
Andrew, D ;
Craig, AD .
NATURE NEUROSCIENCE, 2001, 4 (01) :72-77
[5]  
[Anonymous], 1981, THERMORECEPTION TEMP
[6]  
[Anonymous], 1993, DESCARTES ERROR EMOT
[7]   Responses of primate caudal parabrachial nucleus and Kolliker-Fuse nucleus neurons to whole body rotation [J].
Balaban, CD ;
McGee, DM ;
Zhou, JX ;
Scudder, CA .
JOURNAL OF NEUROPHYSIOLOGY, 2002, 88 (06) :3175-3193
[8]   INTEGRATED DEFENSE REACTION ELICITED BY EXCITATORY AMINO-ACID MICROINJECTION IN THE MIDBRAIN PERIAQUEDUCTAL GREY REGION OF THE UNRESTRAINED CAT [J].
BANDLER, R ;
CARRIVE, P .
BRAIN RESEARCH, 1988, 439 (1-2) :95-106
[9]   Pain [J].
Basbaum, AI ;
Woolf, CJ .
CURRENT BIOLOGY, 1999, 9 (12) :R429-R431
[10]   THE NUCLEUS OF THE SOLITARY TRACT IN THE MONKEY - PROJECTIONS TO THE THALAMUS AND BRAIN-STEM NUCLEI [J].
BECKSTEAD, RM ;
MORSE, JR ;
NORGREN, R .
JOURNAL OF COMPARATIVE NEUROLOGY, 1980, 190 (02) :259-282