Study of serum alanine-aminotransferase levels in blood donors in Spain

被引:0
作者
Lozano, M
Cid, J
Bedini, JL
Mazzara, R
Gimenez, N
Mas, E
Ballesta, A
Ordinas, A
机构
[1] Hosp Clin & Prov Barcelona, Dept Hemotherapy & Hemostasis, Barcelona 08036, Spain
[2] Univ Barcelona, Hosp Clin & Prov Barcelona, Dept Biochem, Barcelona, Spain
关键词
alanine aminotransferase; blood donors; Spain; hepatitis; screening;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Objective. Serum alanine-aminotransferase (ALT) is being used as a surrogate test for preventing post-transfusion viral hepatitis. However, ALT elevation is influenced by many factors. We have studied ALT levels in 1,036 consecutive blood donors to determine their association with gender, obesity, and hepatitis virus infection markers. Design and Methods. In each donation aspartate-aminotransferase (AST), lactate dehydrogenase (LDH) and gamma-glutamyl transferase (gamma GT) activity were also determined and body mass index (BMI) was calculated. Results. Five hundred seventy-nine men and 457 women donated blood; ALT activity was 25.3+/-14.5 IU/L (mean+/-SD) for men and 16.3+/-7.9 IU/L for women (p less than or equal to 0.0005). The upper normal value for men was 56 IU/L and 34 IU/L for women. On applying this value to the study group 4.8% of the men and 2% of the women had values greater than the cutoff. Among the men with increased ALT levels, 53.5% had a BMI >27, 7.1% also had an increased level of GGT and 7.1% had increased levels of AST and LDH. None of them were HBsAg nor anti-HCV positive. Among the women with increased ALT, 33.3% had BMI >27, 33.3% had increased levels of LDH and AST, and 11.1% were anti-NOV positive (only 1 donor). Interpretation and Conclusions. It seems clear that different cutoff values should be considered for men and women. Factors such as obesity, may account for more than 50% of the cases with increased ALT values, indicating the low specificity of the test. (C) 1998, Ferrata Storti Foundation.
引用
收藏
页码:237 / 239
页数:3
相关论文
共 21 条
[1]  
*AABB, 1995, ASS B, V956
[2]   UK MULTICENTER STUDY ON BLOOD-DONORS FOR SURROGATE MARKERS OF NON-A-HEPATITIS NON-B-HEPATITIS .1. ALANINE TRANSFERASE AND ANTI-HBC TESTING [J].
ANDERSON, NAB ;
RAAFAT, A ;
SHWE, KH ;
BARBARA, J ;
CONTRERAS, M ;
FRASER, ID ;
GUNSON, HH ;
MARTLEW, V ;
MIJOVIC, V ;
GOLDIE, DJ ;
SENEVIRATNE, CJ ;
BENDLE, A ;
BRIGGS, M ;
PAVER, K .
TRANSFUSION MEDICINE, 1992, 2 (04) :301-310
[3]  
[Anonymous], 1985, Ann Intern Med, V103, P147
[4]  
BIZZARO N, 1992, ITAL J GASTROENTEROL, V24, P237
[5]   POSTTRANSFUSION HEPATITIS - IMPACT OF NON-A, NON-B-HEPATITIS SURROGATE TESTS [J].
BLAJCHMAN, MA ;
BULL, SB ;
FEINMAN, SV .
LANCET, 1995, 345 (8941) :21-25
[6]   HOW TO DETERMINE THE ALANINE-AMINOTRANSFERASE THRESHOLD IN BLOOD-DONORS [J].
BOUDART, D ;
BEAUPLET, A ;
MULLER, JY .
VOX SANGUINIS, 1993, 65 (02) :159-160
[7]   SERUM ALT LEVELS - EFFECT OF SEX, RACE, AND OBESITY ON UNIT REJECTION RATE [J].
BRIERE, RO .
TRANSFUSION, 1988, 28 (04) :392-393
[8]   Declining value of alanine aminotransferase in screening of blood donors to prevent posttransfusion hepatitis B and C virus infection [J].
Busch, MP ;
Korelitz, JJ ;
Kleinman, SH ;
Lee, SR ;
AuBuchon, JP ;
Schreiber, GB ;
Williams, AE ;
Ownby, HE ;
Waxman, DA ;
Hutching, S ;
Murphy, EL ;
Gilcher, RO ;
Smith, JW ;
Thomson, RA ;
Nemo, GJ ;
Zuck, TF .
TRANSFUSION, 1995, 35 (11) :903-910
[9]   Limited utility of alanine aminotransferase screening of hepatitis C antibody-screened blood donors [J].
Cable, R ;
Badon, S ;
Pray, C ;
Popovsky, MA .
TRANSFUSION, 1997, 37 (02) :206-210
[10]   Non-specific and specific anti-HCV results correlated to age, sex, transaminase, rhesus blood group and follow-up in blood donors [J].
Caspari, G ;
Gerlich, WH ;
Beyer, J ;
Schmitt, H .
ARCHIVES OF VIROLOGY, 1997, 142 (03) :473-489