Photodynamic therapy (PDT) using topically applied δ-aminolevulinic acid (ALA) for the treatment of oral leukoplakia

被引：84
作者：
Sieron, A
Adamek, M
Kawczyk-Krupka, A
Mazur, S
Ilewicz, L
机构：
[1] Silesian Med Univ, Ctr Laser Diagnost & Therapy, Dept Internal Dis & Phys Med, PL-41902 Bytom, Poland
[2] Silesian Med Univ, Ctr Laser Diagnost & Therapy, Clin Internal Dis & Phys Med, PL-41902 Bytom, Poland
[3] Silesian Med Univ, Dept Conservat Dent & Periodontol, PL-41902 Bytom, Poland
来源：
JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2003年 / 32卷 / 06期
关键词：
delta-aminolevulinic acid (ALA); oral leukoplakia; photodynamic therapy;
D O I：
10.1034/j.1600-0714.2003.00068.x
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Background: Photodynamic therapy (PDT) is a non-invasive method for topical and selective treatment of pre-malignant lesions of oral cavity. The aim of our study was to determine therapeutic response to PDT in patients with oral leukoplakia. Methods: Twelve patients participated in our study. Lesions affected a variety of intraoral sites. The most common location was buccal, gingival and mandibular mucosa. Patients were treated with topically applied 10% delta-aminolevulinic acid (ALA) and light from an argon-pumped dye laser. Irradiation was performed in several (6-8) sessions using light at 635 nm wavelength, delivering a total dose of 100 J/cm(2) per session. Results: A complete response was obtained in 10 out of 12 treated patients. One recurrence was observed during 6 months. Conclusion: Photodynamic therapy appears to be a feasible alternative to conventional therapy of pre-malignant lesions of oral cavity.
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页码：330 / 336
页数：7
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