Interrelationship of Neurogenic Obesity and Chronic Neuropathic Pain in Persons With Spinal Cord Injury

被引：12

作者：

Felix, Elizabeth R. ^{[1
,2
]}

Gater, David R., Jr. ^{[1
,3
]}

机构：

[1] Univ Miami, Dept Phys Med & Rehabil, Miller Sch Med, POB 016960,C-206, Miami, FL 33101 USA

[2] Miami Vet Affairs VA Healthcare Syst, Res Serv, Miami, FL USA

[3] Univ Miami, Miami Project Cure Paralysis, Miller Sch Med, Miami, FL 33101 USA

来源：

TOPICS IN SPINAL CORD INJURY REHABILITATION | 2021年 / 27卷 / 01期

关键词：

adipokines; chronic pain; inflammation; neuropathic pain; obesity; spinal cord injury; IMPAIRED GLUCOSE-TOLERANCE; ASSOCIATION; PREVALENCE; RISK; CLASSIFICATION; SENSITIVITY; POLYNEUROPATHY; INFLAMMATION; INDIVIDUALS; VALIDATION;

D O I：

10.46292/sci20-00062

中图分类号：

R49 [康复医学];

学科分类号：

100215 ;

摘要：

The prevalence of obesity and of neuropathic pain are both estimated at above 50% in the population of people with chronic spinal cord injury (SCI). These secondary consequences of SCI have significant negative impact on physical functioning, activities of daily living, and quality of life. Investigations of relationships between weight or body composition and chronic neuropathic pain in people with SCI are lacking, but investigations in non-SCI cohorts suggest an association between obesity and the presence and severity of neuropathic pain conditions. In the present article, we present a review of the literature linking obesity and neuropathic pain and summarize findings suggesting that metabolic syndrome and chronic, systemic inflammation due to excess adiposity increase the risk for neuropathic pain after an SCI.

引用

页码：75 / 83

页数：9

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