Deletion of 3′-CBFB gene in association with an inversion (16)(p13q22) and a loss of the Y chromosome in a 2-year-old child with acute myelogenous leukemia-M4

被引：9
作者：
Batanian, JR
Huang, YF
Fallon, R
机构：
[1] St Louis Univ, Cardinal Glennon Childrens Hosp, Dept Pediat, Mol Cytogenet Lab, St Louis, MO 63104 USA
[2] St Louis Univ, Pediat Res Inst, Dept Pediat & Hematol Oncol, St Louis, MO 63103 USA
来源：
CANCER GENETICS AND CYTOGENETICS | 2000年 / 121卷 / 02期
关键词：
D O I：
10.1016/S0165-4608(00)00251-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Inversion 16(p13q22) is most commonly associated with acute myelomonocytic leukemia with abnormal eosinophils (M4). III association with this inversion, a proximal deletion at the 16p13 primary arm breakpoint occurs in 20% of cases. We report on a first case of inversion IG with a distal deletion at the primary arm breakpoint 16q22, detected by using the fluorescent-labeled dual-color probe CBFB. (C) 2000 Elsevier Science Inc. All rights reserved.
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页码：216 / 219
页数：4
相关论文
共 11 条
[1]  
CLAXTON DF, 1994, BLOOD, V83, P1750
[2]   Two-colour FISH detection of the inv(16) in interphase nuclei of patients with acute myeloid leukaemia [J].
Dauwerse, HG ;
Smit, EME ;
Giles, RH ;
Slater, R ;
Breuning, MH ;
Hagemijer, A ;
van der Reijden, BA .
BRITISH JOURNAL OF HAEMATOLOGY, 1999, 106 (01) :111-114
[3]  
DAUWERSE JG, 1993, HUM MOL GENET, V10, P527
[4]  
Dierlamm J, 1998, GENE CHROMOSOME CANC, V22, P87, DOI 10.1002/(SICI)1098-2264(199806)22:2<87::AID-GCC1>3.0.CO
[5]  
2-2
[6]  
GRIFFITHS MJ, 1992, GENE CHROMOSOME CANC, V5, P83
[7]   ASSOCIATION OF AN INVERSION OF CHROMOSOME-16 WITH ABNORMAL MARROW EOSINOPHILS IN ACUTE MYELOMONOCYTIC LEUKEMIA - A UNIQUE CYTOGENETIC CLINICOPATHOLOGICAL ASSOCIATION [J].
LEBEAU, MM ;
LARSON, RA ;
BITTER, MA ;
VARDIMAN, JW ;
GOLOMB, HM ;
ROWLEY, JD .
NEW ENGLAND JOURNAL OF MEDICINE, 1983, 309 (11) :630-636
[8]   FUSION BETWEEN TRANSCRIPTION FACTOR CBF-BETA/PEBP2-BETA AND A MYOSIN HEAVY-CHAIN IN ACUTE MYELOID-LEUKEMIA [J].
LIU, P ;
TARLE, SA ;
HAJRA, A ;
CLAXTON, DF ;
MARLTON, P ;
FREEDMAN, M ;
SICILIANO, MJ ;
COLLINS, FS .
SCIENCE, 1993, 261 (5124) :1041-1044
[9]   MOLECULAR PATHOGENESIS OF THE CHROMOSOME-16 INVERSION IN THE M4EO SUBTYPE OF ACUTE MYELOID-LEUKEMIA [J].
LIU, PP ;
HAJRA, A ;
WIJMENGA, C ;
COLLINS, FS .
BLOOD, 1995, 85 (09) :2289-2302
[10]   MOLECULAR CHARACTERIZATION OF 16P DELETIONS ASSOCIATED WITH INVERSION-16 DEFINES THE CRITICAL FUSION FOR LEUKEMOGENESIS [J].
MARLTON, P ;
CLAXTON, DF ;
LIU, P ;
ESTEY, EH ;
BERAN, M ;
LEBEAU, M ;
TESTA, JR ;
COLLINS, FS ;
ROWLEY, JD ;
SICILIANO, MJ .
BLOOD, 1995, 85 (03) :772-779
12