Concomitant chemoradiotherapy for advanced squamous cell carcinoma of the temporal bone

被引：38

作者：

Shinomiya, Hirotaka ^{[1
]}

Hasegawa, Shingo ^{[1
]}

Yamashita, Daisuke ^{[1
]}

Ejima, Yasuo ^{[2
]}

Kenji, Yoshida ^{[2
]}

Otsuki, Naoki ^{[1
]}

Kiyota, Naomi ^{[3
]}

Sakakibara, Shunsuke ^{[4
]}

Nomura, Tadashi ^{[4
]}

Hashikawa, Kazunobu ^{[4
]}

Kohmura, Eiji ^{[5
]}

Sasaki, Ryohei ^{[2
]}

Nibu, Ken-ichi ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Chuo Ku, 7-5-1 Kusunoki Cho, Kobe, Hyogo 6500017, Japan

[2] Kobe Univ, Grad Sch Med, Dept Radiat Oncol, Chuo Ku, Kobe, Hyogo 6500017, Japan

[3] Kobe Univ, Grad Sch Med, Dept Med Oncol Hematol, Chuo Ku, Kobe, Hyogo 6500017, Japan

[4] Kobe Univ, Grad Sch Med, Dept Plast Surg, Chuo Ku, Kobe, Hyogo 6500017, Japan

[5] Kobe Univ, Grad Sch Med, Dept Neurosurg, Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2016年 / 38卷

关键词：

ear cancer; temporal bone; concomitant chemoradiotherapy; cisplatin; docetaxel; RESECTION; OUTCOMES; SURVIVAL;

D O I：

10.1002/hed.24133

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. The purpose of this study was to analyze outcomes for the treatment of locally advanced temporal bone cancer by means of concomitant chemoradiotherapy (CCRT) with a combination of cisplatin (CDDP), 5-fluorouracil (5-FU), and docetaxel (TPF). Methods. Between 2006 and 2011, 34 patients with squamous cell carcinoma of the temporal bone were treated at Kobe University Hospital. Medical records were retrospectively reviewed to obtain information concerning patient characteristics, extent of disease, treatment, adverse events, and oncologic results. Results. Ten patients were treated with CCRT using TPF regimen. The 5-year overall survival rate and disease-free survival rate were both 60%. Of special interest is that even for patients with unresectable T4 disease, the 5-year overall survival rate was 56%. Conclusion. The results of our study indicate that CCRT with TPF for locally advanced temporal bone cancer is an effective and promising regimen. (c) 2015 Wiley Periodicals, Inc.

引用

页码：E949 / E953

页数：5

共 15 条

[1] Squamous cell carcinoma of the temporal bone [J].