A Left-Handed Solution to Peptide Inhibition of the p53-MDM2 Interaction

被引：93

作者：

Liu, Min ^{[1
,2
]}

Pazgier, Marzena ^{[1
]}

Li, Changqing ^{[1
]}

Yuan, Weirong ^{[1
]}

Li, Chong ^{[1
]}

Lu, Wuyuan ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA

[2] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Xian, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 21期

基金：

美国国家卫生研究院;

关键词：

antitumor agents; p53; MDM2; protein-protein interactions; protein structures; PROTEIN-PROTEIN INTERACTIONS; P53; PATHWAY; IN-VIVO; MDM2; ACTIVATION; APOPTOSIS; HELIX;

D O I：

10.1002/anie.201000329

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Throwing tumors a left-hook punch: The oncoprotein MDM2 negatively regulates the activity and stability of the tumor suppressor protein p53, and is an important molecular target for anticancer therapy. Mirror-image phage display identified a high-affinity D-peptide ligand of MDM2 (see structure) that could be developed into a potent and protease-resistant p53 activator with potential antitumor activity. (Figure Presented) © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3649 / 3652

页数：4

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