Effects of prenatal exposure to ambient air pollutant PM10 on ultrasound-measured fetal growth

被引:33
作者
Zhao, Nan [1 ,2 ]
Qiu, Jie [3 ]
Ma, Shuangge [4 ]
Zhang, Yaqun [5 ]
Lin, Xiaojuan [3 ]
Tang, Zhongfeng [3 ]
Zhang, Honghong [3 ]
Huang, Huang [6 ]
Ma, Ning [7 ]
Huang, Yuan [4 ]
Bell, Michelle L. [8 ]
Liu, Qing [3 ]
Zhang, Yawei [2 ,6 ]
机构
[1] Peking Union Med Coll Hosp, Dept Sci Res, Beijing, Peoples R China
[2] Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA
[3] Gansu Prov Matern & Child Care Hosp, Lanzhou, Gansu, Peoples R China
[4] Yale Sch Publ Hlth, Dept Biostat, New Haven, CT USA
[5] Gansu Acad Environm Sci, Lanzhou, Gansu, Peoples R China
[6] Yale Sch Med, Dept Surg, New Haven, CT USA
[7] Capital Med Univ, Beijing Childrens Hosp, Dept Ecocardiog, Beijing, Peoples R China
[8] Yale Univ, Sch Forestry & Environm Studies, New Haven, CT 06511 USA
基金
美国国家卫生研究院;
关键词
Fetal growth; PM10; air pollution; ultrasound measures; pregnancy; MATERNAL EXPOSURE; PARTICULATE MATTER; BIRTH OUTCOMES; PRETERM BIRTH; WEIGHT-GAIN; PREGNANCY; COHORT; EXPRESSION; OBESITY; ASSOCIATION;
D O I
10.1093/ije/dyy019
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: Limited epidemiological studies have investigated the relationship between prenatal exposure to ambient particulate matter and risk of abnormal fetal growth, and have reached inconclusive results. No study has been conducted in areas with very high air pollution levels. We investigated the hypothesis that exposure to high levels of particulate matter with aerodynamic diameter no larger than 10 mm (PM10) during pregnancy increases the risk of abnormal fetal growth. Methods: A birth cohort study was performed in Lanzhou, China, 2010-12, including 8877 pregnant women with 18 583 ultrasound measurements of four fetal growth parameters during pregnancy, including biparietal diameter (BPD), femur length (FL), head circumference (HC) and abdominal circumference (AC). Mixed-effects modelling was used to examine the associations between PM10 exposure and risk of abnormal fetal growth. Results: When average PM10 exposure from conception until the ultrasound examination exceeded 150 mu g/m(3), there were significant increases in standardized FL (beta = 0.095, P = 0.0012) and HC (beta = 0.090, P = 0.0078) measures. When average PM10 exposure was treated as continuous variable, we found a significant decrease in standardized BPD (beta = -0.018, P = 0.0016) as per 10 mu g/m(3) increase in PM10. After examining the associations by various exposure windows, positive associations between higher levels of PM10 and fetal overgrowth were consistently seen for HC measures. Conclusions: Our study suggested that prenatal exposure to high levels of ambient PM10 increased the risk of abnormal fetal growth. The findings from our study have important public health implications and also call for future studies to explore the underlying mechanisms and post-natal consequences of these findings.
引用
收藏
页码:1072 / 1081
页数:10
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