A quantitative structure-activity relationship study on a series of Na+, K+-ATPase inhibitors

被引：2
|
作者：
Gupta, SP [1 ]
Bagaria, P
Kumaran, S
机构：
[1] Birla Inst Technol & Sci, Dept Chem, Pilani 333031, Rajasthan, India
[2] Birla Inst Technol & Sci, Dept Pharm, Pilani 333031, Rajasthan, India
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2004年 / 19卷 / 05期
关键词：
quantitative structure-activity relationship (QSAR); Na+; K+-ATPase inhibitors; digitalis-like compounds; cardiotonics;
D O I：
10.1080/1475636042000206437
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A quantitative structure-activity relationship ( QSAR) study has been made on a new series of digitalis-like Na+, K+-ATPase inhibitors in which the guanylhydrazone group has been replaced by an aminoalkyloxime group. The correlations obtained have shown that the oxime moiety, primary amine group, overall size, and polarizability of the new type of substituents are higly beneficial to the Na+, K+-ATPase inhibition potency of the compounds and that their effect can be quantitatively assessed. The study also showed that the inotropic activity of the compounds is very well correlated with their Na+, K+-ATPase inhibition potency.
引用
收藏
页码：389 / 393
页数：5
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