Highly efficient ortho-fluoro-dimeric cinchona-derived phase-transfer catalysts

被引：61

作者：

Park, HG ^{[1
]}

Jeong, BS

Yoo, MS

Lee, JH

Park, BS

Kim, MG

Jew, SS

机构：

[1] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(03)00687-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of cinchona alkaloid-derived dimeric quaternary ammonium salts were prepared as chiral phase-transfer catalysts by the introduction of various functional groups on the phenyl ligand. Among them, the 2-F-substituted derivative 21 showed the highest enantioselectivity in the alkylation of the glycine anion equivalent 1 (97 to >99% ee). (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：3497 / 3500

页数：4

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