Nickel-Catalyzed Arylative Carboxylation of Alkynes with Arylmagnesium Reagents and Carbon Dioxide Leading to Trisubstituted Acrylic Acids

被引：39
作者：
Wang, Sheng [1 ]
Xi, Chanjuan [1 ,2 ]
机构：
[1] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, MOE, Beijing 100084, Peoples R China
[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 13期
基金：
中国国家自然科学基金;
关键词：
ARYL GRIGNARD-REAGENTS; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; CO2; HYDROCARBOXYLATION; DERIVATIVES; ALKENES; HALIDES; BONDS; TRANSFORMATIONS;
D O I：
10.1021/acs.orglett.8b01693
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Nickel-catalyzed arylcarboxylation of alkynes with arylmagnesium reagents and carbon dioxide (CO2, 1 atm) was realized in one pot. Various trisubstituted acrylic acids within an aryl group at the beta-position have been prepared efficiently with good regioselectivity under mild conditions. The resulting products could be further transformed to benzoannelated cycles retaining CO2 as a one-carbon synthon.
引用
收藏
页码：4131 / 4134
页数：4
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