Why BRCA mutations are not tumour-agnostic biomarkers for PARP inhibitor therapy

被引：20

作者：

Curtin, Nicola J. ^{[1
]}

Drew, Yvette ^{[1
]}

Sharma-Saha, Sweta ^{[1
]}

机构：

[1] Newcastle Univ, Northern Inst Canc Res, Newcastle Upon Tyne, Tyne & Wear, England

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2019年 / 16卷 / 12期

关键词：

POLY(ADP-RIBOSE) POLYMERASE; HOMOLOGOUS RECOMBINATION; OVARIAN-CARCINOMA; CANCER; CELLS;

D O I：

10.1038/s41571-019-0285-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BRCA1/2 mutations and poly (ADP-ribose) polymerase (PARP) inhibitors are paradigmatic of synthetic lethal therapy. However, the activity of PARP inhibitors seems to vary considerably across BRCA1/2-mutant cancers and new insights into the tumour-lineage dependency of this synthetic lethal relationship might explain why BRCA1/2 mutations are not tumour-agnostic biomarkers of a response to PARP inhibitors.

引用

页码：725 / 726

页数：2

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