Sorting out the multiple roles of Fas ligand

被引：17

作者：

Bossi, G

Stinchcombe, JC

Page, LJ

Griffiths, GM

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

[2] Imperial Canc Res Fund, Labs, London WC2A 3PX, England

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2000年 / 79卷 / 08期

基金：

英国惠康基金;

关键词：

Fas ligand (CD95 ligand); cytotoxic T lymphocyte; sorting; secretory lysosome;

D O I：

10.1078/0171-9335-00077

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fas ligand can both be used by the immune system to initiate cell death, and be used by non-lymphoid cells to evade death. Recent work has shown that Fas ligand is differentially sorted in different cell type!;. Here we present the viewpoint that the differential sorting prays an important part in determining the role of Fas ligand in different cells.

引用

收藏

页码：539 / 543

页数：5

相关论文

共 35 条

[1] Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts [J].

Allison, J ;

Georgiou, HM ;

Strasser, A ;

Vaux, DL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :3943-3947

[2] Two signaling pathways can lead to Fas ligand expression in CD8(+) cytotoxic T lymphocyte clones [J].

Anel, A ;

Simon, AK ;

Auphan, N ;

Buferne, M ;

Boyer, C ;

Golstein, P ;

SchmittVerhulst, AM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (12) :3381-3387

[3] Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells [J].

Bonfoco, E ;

Stuart, PM ;

Brunner, T ;

Lin, T ;

Griffith, TS ;

Gao, Y ;

Nakajima, H ;

Henkart, PA ;

Ferguson, TA ;

Green, DR .

IMMUNITY, 1998, 9 (05) :711-720

[4] Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells [J].

Bossi, G ;

Griffiths, GM .

NATURE MEDICINE, 1999, 5 (01) :90-96

[5] CELL-AUTONOMOUS FAS (CD95) FAS-LIGAND INTERACTION MEDIATES ACTIVATION-INDUCED APOPTOSIS IN T-CELL HYBRIDOMAS [J].

BRUNNER, T ;

MOGIL, RJ ;

LAFACE, D ;

YOO, NJ ;

MAHBOUBI, A ;

ECHEVERRI, F ;

MARTIN, SJ ;

FORCE, WR ;

LYNCH, DH ;

WARE, CF ;

GREEN, DR .

NATURE, 1995, 373 (6513) :441-444

[6] AUTOCRINE T-CELL SUICIDE MEDIATED BY APO-1/(FAS/CD95) [J].

DHEIN, J ;

WALCZAK, H ;

BAUMLER, C ;

DEBATIN, KM ;

KRAMMER, PH .

NATURE, 1995, 373 (6513) :438-441

[7] LYSOSOMAL HYDROLASES ARE PRESENT IN MELANOSOMES AND ARE ELEVATED IN MELANIZING CELLS [J].

DIMENT, S ;

EIDELMAN, M ;

RODRIGUEZ, GM ;

ORLOW, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (09) :4213-4215

[8] 2 BINDING ORIENTATIONS FOR PEPTIDES TO THE SRC SH3 DOMAIN - DEVELOPMENT OF A GENERAL-MODEL FOR SH3-LIGAND INTERACTIONS [J].

FENG, SB ;

CHEN, JK ;

YU, HT ;

SIMON, JA ;

SCHREIBER, SL .

SCIENCE, 1994, 266 (5188) :1241-1247

[9]

Glass A, 1996, J IMMUNOL, V156, P3638

[10] FAS LIGAND-INDUCED APOPTOSIS AS A MECHANISM OF IMMUNE PRIVILEGE [J].

GRIFFITH, TS ;

BRUNNER, T ;

FLETCHER, SM ;

GREEN, DR ;

FERGUSON, TA .

SCIENCE, 1995, 270 (5239) :1189-1192

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