Evolving Role of Radiotherapy in the Management of Rectal Carcinoma

被引：4

作者：

Smith, Clayton A. ^{[1
]}

Kachnic, Lisa A. ^{[2
]}

机构：

[1] Univ S Alabama, Div Radiat Oncol, Mitchell Canc Inst, 1660 Spring Hill Ave, Mobile, AL 36604 USA

[2] Vanderbilt Univ, Med Ctr, Dept Radiat Oncol, 2220 Pierce Ave,Preston Res Bldg B-1003, Nashville, TN 37232 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2017年 / 26卷 / 03期

关键词：

Rectal; Cancer; Radiotherapy; Radiation; Neoadjuvant; Intensity-modulated radiation therapy; TOTAL MESORECTAL EXCISION; PATHOLOGICAL COMPLETE RESPONSE; MODULATED RADIATION-THERAPY; COMPLETE CLINICAL-RESPONSE; PHASE-III TRIAL; PREOPERATIVE RADIOTHERAPY; LOCAL RECURRENCE; RANDOMIZED-TRIAL; POSTOPERATIVE CHEMORADIOTHERAPY; NEOADJUVANT CHEMORADIOTHERAPY;

D O I：

10.1016/j.soc.2017.01.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Management of locally advanced rectal cancer has evolved over time from surgical resection alone to multimodality therapy with preoperative radiation, chemotherapy, and total mesorectal excision resulting in excellent local control rates. Refinements in neoadjuvant therapies and their sequencing have improved pathologic complete response rates such that consideration of selective radiation and nonoperative management are now active clinical trial questions. Advances in radiation treatment planning and delivery techniques may allow for further reduction in acute treatment-related toxicity in select patient populations. Collectively, therapeutic strategies remain focused on improving outcomes for patients with higher-risk disease and reducing the morbidity of treatment.

引用

页码：455 / +

页数：13

共 45 条

[1]

Allegra CJ, 2015, J NATL CANC I, V107

[2] High-dose chemoradiotherapy and watchful waiting for distal rectal cancer: a prospective observational study [J].

Appelt, Ane L. ;

Ploen, John ;

Harling, Henrik ;

Jensen, Frank S. ;

Jensen, Lars H. ;

Jorgensen, Jens C. R. ;

Lindebjerg, Jan ;

Rafaelsen, Soren R. ;

Jakobsen, Anders .

LANCET ONCOLOGY, 2015, 16 (08) :919-927

[3] Predictors of Pathologic Complete Response After Neoadjuvant Treatment for Rectal Cancer: A Multicenter Study [J].

Armstrong, Dawn ;

Raissouni, Soundouss ;

Hiller, Julie Price ;

Mercer, Jamison ;

Powel, Erin ;

MacLean, Anthony ;

Jiang, Maria ;

Doll, Corinne ;

Goodwin, Rachel ;

Batuyong, Eugene ;

Zhou, Kevin ;

Monzon, Jose G. ;

Tang, Patricia A. ;

Heng, Daniel Y. ;

Cheung, Winson Y. ;

Vickers, Michael M. .

CLINICAL COLORECTAL CANCER, 2015, 14 (04) :291-295

[4] What is the clinical benefit of preoperative chemoradiotherapy with 5FU/leucovorin for T3-4 rectal cancer in a pooled analysis of EORTC 22921 and FFCD 9203 trials: Surrogacy in question? [J].

Bonnetain, F. ;

Bosset, J. F. ;

Gerard, J. P. ;

Calais, G. ;

Conroy, T. ;

Mineur, L. ;

Bouche, O. ;

Maingon, P. ;

Chapet, O. ;

Radosevic-Jelic, L. ;

Methy, N. ;

Collette, L. .

EUROPEAN JOURNAL OF CANCER, 2012, 48 (12) :1781-1790

[5] Chemotherapy with preoperative radiotherapy in rectal cancer [J].

Bosset, Jean-Francois ;

Collette, Laurence ;

Calais, Gilles ;

Mineur, Laurent ;

Maingon, Philippe ;

Radosevic-Jelic, Ljiljana ;

Daban, Alain ;

Bardet, Etienne ;

Beny, Alexander ;

Ollier, Jean-Claude .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (11) :1114-1123

[6] Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study [J].

Bosset, Jean-Francois ;

Calais, Gilles ;

Mineur, Laurent ;

Maingon, Philippe ;

Stojanovic-Rundic, Suzana ;

Bensadoun, Rene-Jean ;

Bardet, Etienne ;

Beny, Alexander ;

Ollier, Jean-Claude ;

Bolla, Michel ;

Marchal, Dominique ;

Van Laethem, Jean-Luc ;

Klein, Vincent ;

Giralt, Jordi ;

Clavere, Pierre ;

Glanzmann, Christoph ;

Cellier, Patrice ;

Collette, Laurence .

LANCET ONCOLOGY, 2014, 15 (02) :184-190

[7] Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer [J].

Bujko, K. ;

Nowacki, M. P. ;

Nasierowska-Guttmejer, A. ;

Michalski, W. ;

Bebenek, M. ;

Kryj, M. .

BRITISH JOURNAL OF SURGERY, 2006, 93 (10) :1215-1223

[8] Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy [J].

Bujko, K ;

Nowacki, MP ;

Nasierowska-Guttmejer, A ;

Michalski, W ;

Bebenek, AB ;

Pudelko, M ;

Kryj, A ;

Oledzki, J ;

Szmeja, J ;

Sluszniak, J ;

Serkies, K ;

Kladny, J ;

Pamucka, A ;

Kukolowicz, P .

RADIOTHERAPY AND ONCOLOGY, 2004, 72 (01) :15-24

[9] Modified FOLFOX6 With or Without Radiation Versus Fluorouracil and Leucovorin With Radiation in Neoadjuvant Treatment of Locally Advanced Rectal Cancer: Initial Results of the Chinese FOWARC Multicenter, Open-Label, Randomized Three-Arm Phase III Trial [J].

Deng, Yanhong ;

Chi, Pan ;

Lan, Ping ;

Wang, Lei ;

Chen, Weiqing ;

Cui, Long ;

Chen, Daoda ;

Cao, Jie ;

Wei, Hongbo ;

Peng, Xiang ;

Huang, Zonghai ;

Cai, Guanfu ;

Zhao, Ren ;

Huang, Zhongcheng ;

Xu, Lin ;

Zhou, Hongfeng ;

Wei, Yisheng ;

Zhang, Hao ;

Zheng, Jian ;

Huang, Yan ;

Zhou, Zhiyang ;

Cai, Yue ;

Kang, Liang ;

Huang, Meijin ;

Peng, Junsheng ;

Ren, Donglin ;

Wang, Jianping .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (27) :3300-+

[10] Chemoradiation, surgery and adjuvant chemotherapy versus induction chemotherapy followed by chemoradiation and surgery: long-term results of the Spanish GCR-3 phase II randomized trial [J].

Fernandez-Martos, C. ;

Garcia-Albeniz, X. ;

Pericay, C. ;

Maurel, J. ;

Aparicio, J. ;

Montagut, C. ;

Safont, M. J. ;

Salud, A. ;

Vera, R. ;

Massuti, B. ;

Escudero, P. ;

Alonso, V. ;

Bosch, C. ;

Martin, M. ;

Minsky, B. D. .

ANNALS OF ONCOLOGY, 2015, 26 (08) :1722-1728

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