Lymphoma in HIV 1-infected children.

被引：6
作者：
Gandemer, V
Verkarre, V
Quartier, P
Brousse, N
Blanche, S
机构：
[1] Hop Necker Enfants Malad, Unite Immunol Hematol Pediat, F-75743 Paris 15, France
[2] Hop Necker Enfants Malad, Serv Anat & Cytol Pathol, F-75743 Paris 15, France
来源：
ARCHIVES DE PEDIATRIE | 2000年 / 7卷 / 07期
关键词：
lymphoma; AIDS related; HIV-1; antineoplastic agents; combined; child;
D O I：
10.1016/S0929-693X(00)80154-2
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Purpose. - To describe the features of lymphoma in human immunodeficiency virus (HIV)-infected children, their treatments and the outcome of patients. Results. - We analyzed seven HIV-infected children (four by mother-to-child transmission and three by transfusion) (25 months to 18.5 years old) with lymphoma (one Hodgkin's disease and six non-Hodgkin's lymphomas). All of them presented with a severe immunodepression and a high viral load. Five of six were high grade-B cell non-Hodgkin's lymphoma of large-cell histologies (immunoblastic or centroblastic). Five were extranodular disease and three were metastatic at diagnosis. Epstein-Barr virus was detected in four tumors. Five of seven received a multiagent chemotherapy. Toxicity was high. Treatment for the skin T lymphoma consisted of radiation therapy. Five children were complete responders (with survival three years, 2.5 years, 12, 18 and 18 months) and two died of progression of lymphoma (four and five months later).
引用
收藏
页码：738 / 744
页数：7
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