Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature review

被引:29
作者
Sisti, Andrea [1 ]
Sisti, Giovanni [1 ]
Oranges, Carlo Maria [1 ]
机构
[1] Via Venezia 6, I-51016 Montecatini Terme, Pistoia, Italy
关键词
Ointments; Tacrolimus; Vitiligo; 0.1-PERCENT TACROLIMUS; DOUBLE-BLIND; OINTMENT; EFFICACY; UVB; 0.05-PERCENT; CLOBETASOL; THERAPY; TRIAL; SKIN;
D O I
10.1590/abd1806-4841.20164012
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Thus far, several small studies and case reports on the use of topical immunomodulators in vitiligo have been published. We undertook a comprehensive literature review, searching for studies evaluating clinical response to tacrolimus topical therapy for vitiligo. A search was performed on PubMed/Medline using the term "vitiligo", combined with "topical" and "ointment". Our inclusion criteria were: use of tacrolimus ointment as monotherapy to treat vitiligo. We found 29 studies from 2002 to 2014. Overall, 709 patients were treated in 29 studies. Pooling the lesions, 50% repigmentation of vitiligo patches was never achieved before 2 months of treatment, with a peak after 6 months of therapy. The best results were obtained on lesions of the cephalic region, especially the face, with tacrolimus 0.1% ointment two times daily. The percentage of non-responsive patients ranged from 0% to 14%. Treatment was generally well-tolerated; only localized adverse effects were reported. Our objective was to verify the effectiveness and safety of tacrolimus ointment monotherapy. It has good efficacy and tolerability. At present, only small trials and case series are available in the literature. Further, standardized investigations on a larger number of patients are needed.
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收藏
页码:187 / 195
页数:9
相关论文
共 34 条
[1]  
Allam Mohamed, 2013, Qatar Med J, V2013, P1, DOI 10.5339/qmj.2013.10
[2]   VITILIGO. TREATMENT OF 12 CASES WITH TOPICAL TACROLIMUS [J].
Almeida, Pablo ;
Borrego, Leopoldo ;
Rodriguez-Lopez, Julio ;
Lujan, Dunia ;
Cameselle, Daniel ;
Hernandez, Buenaventura .
ACTAS DERMO-SIFILIOGRAFICAS, 2005, 96 (03) :159-163
[3]   Focal acne during topical tacrolimus therapy for vitiligo [J].
Bakos, Lucio ;
Bakos, Renato Marchiori .
ARCHIVES OF DERMATOLOGY, 2007, 143 (09) :1223-1224
[4]  
Baldo A, 2014, GIORN ITAL DERMAT V, V149, P123
[5]  
Begum R, 2014, MOL CYTOGENET, V7, P157
[6]  
Bhuvana K, 2011, Indian J Dermatol, V56, P445, DOI 10.4103/0019-5154.84735
[7]   Topical immunomodulators are effective for treatment of vitiligo [J].
Choi, Chong Won ;
Chang, Sung Eun ;
Bak, Hana ;
Choi, Jee Ho ;
Park, Hyun Sun ;
Huh, Chang Hun ;
Kim, Chan Woong ;
Kim, Sung Eun ;
Mun, Seog Kyun ;
Kim, Beom Joon ;
Kim, Myeung Nam .
JOURNAL OF DERMATOLOGY, 2008, 35 (08) :503-507
[8]  
De Dipankar, 2008, Skinmed, V7, P93, DOI 10.1111/j.1751-7125.2008.07558.x
[9]   Topical tacrolimus therapy for vitiligio: Therapeutic responses and skin messenger RNA expression of proinflammatory cytokines [J].
Grimes, PE ;
Morris, R ;
Avaniss-Aghajani, E ;
Soriano, T ;
Meraz, M ;
Metzger, A .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2004, 51 (01) :52-61
[10]   Topical tacrolimus for repigmentation of vitiligo [J].
Grimes, PE ;
Soriano, T ;
Dytoc, MT .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2002, 47 (05) :789-791