Histone Chaperones, Histone Acetylation, and the Fluidity of the Chromogenome

被引：23

作者：

Hansen, Jeffrey C. ^{[1
]}

Nyborg, Jennifer K. ^{[1
]}

Luger, Karolin ^{[1
]}

Stargell, Laurie A. ^{[1
]}

机构：

[1] Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2010年 / 224卷 / 02期

基金：

美国国家卫生研究院;

关键词：

NUCLEOSOME ASSEMBLY PROTEIN-1; POLYMERASE-II HOLOENZYME; HEAT-SHOCK FACTOR; TRANSCRIPTIONAL ACTIVATION; ACETYLTRANSFERASE COMPLEX; SACCHAROMYCES-CEREVISIAE; CRYSTAL-STRUCTURE; ADA COMPLEX; DNA-BINDING; FUNCTIONAL INTERACTION;

D O I：

10.1002/jcp.22150

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The "chromogenome" is defined as the structural and functional status of the genome at any given moment within a eukaryotic cell. This article focuses on recently uncovered relationships between histone chaperones, post-translational acetylation of histones, and modulation of the chromogenome. We emphasize those chaperones that function in a replication-independent manner, and for which three-dimensional structural information has been obtained. The emerging links between histone acetylation and chaperone function in both yeast and higher metazoans are discussed, including the importance of nucleosome-free regions. We close by posing many questions pertaining to how the coupled action of histone chaperones and acetylation influences chromogenome structure and function. J. Cell. Physiol. 224: 289-299, 2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：289 / 299

页数：11

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