The impact of postoperative radiological surveillance intensity on disease free and overall survival from primary retroperitoneal, abdominal and pelvic soft-tissue sarcoma

被引：8

作者：

Glasbey, J. C. ^{[1
]}

Bundred, J. ^{[1
]}

Tyler, R. ^{[1
]}

Hunt, J. ^{[1
]}

Tattersall, H. ^{[1
]}

Gourevitch, D. ^{[1
]}

Almond, L. M. ^{[1
]}

Desai, A. D. ^{[1
]}

Ford, S. J. ^{[1
,2
]}

机构：

[1] Queen Elizabeth Hosp Birmingham, Midlands Abdominal & Retroperitoneal Sarcoma Unit, Birmingham B15 2TH, W Midlands, England

[2] Queen Elizabeth Hosp Birmingham, Dept Sarcoma Surg, Birmingham B15 2TH, W Midlands, England

来源：

EJSO | 2021年 / 47卷 / 07期

关键词：

Soft tissue sarcoma; Retroperitoneal sarcoma; Liposarcoma; Leiomyosarcoma; Radiological surveillance; Follow-up; FOLLOW-UP; LOW-GRADE; RECURRENCE; GUIDELINES; MANAGEMENT; RESECTION; PATTERNS; MARGIN;

D O I：

10.1016/j.ejso.2021.01.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: This observational study aimed to evaluate the impact of intensity of radiological surveillance on survival following resection of retroperitoneal sarcoma. Method: Retrospective cohort study of patients undergoing primary resection of soft tissue sarcoma arising in the retroperitoneum, abdomen or pelvis at a single, high-volume sarcoma centre. Intensity of follow-up regimes up to 5 postoperative years were categorized as 'European Society for Medical Oncology (ESMO) compliant' (intense), or 'non-ESMO compliant' (less-intense). The primary outcome measure was overall survival (OS). The secondary outcome measures were disease-free survival (DFS) and reoperation rate. Analyses were stratified by high (grade 2 or 3) or low (grade 1) tumour grade. Results: Of 168 patients, 67.1% had high-grade and 32.9% had low-grade disease. Overall, 40.0% of pa-tients had ESMO-compliant radiological follow-up (high-grade:25.7%, low-grade:66.7%). 41.7% of pa-tients died and 48.2% suffered local or distant recurrence by cessation of follow up. Upon univariable analysis for high-grade tumours, ESMO compliance reduced DFS (p = 0.066) but had no impact on OS. There was no significant difference in the reoperation rate in patients with ESMO-compliant and non-compliant follow-up (p = 0.097). In low-grade tumours, ESMO compliance significantly reduced DFS (p < 0.001), but without effecting OS. In risk-adjusted models for high-grade tumours, ESMO compliant follow-up was associated with reduced OS (HR:3.47, 1.40-8.61, p = 0.007) and no difference in DFS. In low-grade tumours, there was no association between overall ESMO compliance and OS or DFS. Conclusion: This study did not find a benefit for high-intensity radiological surveillance and overall survival in patients undergoing primary resection for high or low-grade retroperitoneal sarcoma. (c) 2021 Elsevier Ltd, BASO -The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

引用

页码：1771 / 1777

页数：7

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