Obstacles to the development of a safe and effective attenuated pre-erythrocytic stage malaria vaccine

被引：15

作者：

Ballou, W. Ripley ^{[1
]}

机构：

[1] GlaxoSmithKline, Worldwide Clin Dev, B-1330 Rixensart, Belgium

来源：

MICROBES AND INFECTION | 2007年 / 9卷 / 06期

关键词：

malaria; sporozoite; attenuated; subunit; vaccine;

D O I：

10.1016/j.micinf.2007.02.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Attenuated pre-erythrocytic stage malaria vaccines protect humans from sporozoite challenge. Current technology limits the feasibility of their commercial scale production and poses a significant risk of contamination with transmissible agents. Overcoming these barriers will be very challenging. In contrast, subunit vaccines appear quite feasible and show great promise as candidate malaria vaccines. (C) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：761 / 766

页数：6

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