Introduction Survival in multiple myeloma (MM) has improved due to the ongoing revolution of therapeutic approaches. Nevertheless, many patients relapse, and additional novel approaches are required to prolong remissions and prevent disease progression. Areas Covered Considering the success of monoclonal antibodies (mAbs) against CD38 and SLAMF7 in relapsed/refractory MM (R/R MM), additional antigens expressed on malignant plasma cells are being investigated as treatment targets. Among these, many trials are focusing on B cell maturation antigen (BCMA), using either antibody-drug conjugates (ADCs), bispecific T cell engagers (TCE), or chimeric antigen receptor T cells (CAR-T). Other potential targets include the myeloma markers CD138, GPRC5D, FcRH5, the plasma cell differentiating factors APRIL, TACI and BAFF, and the immune checkpoint proteins CD47 and TIGIT. Additionally, novel immunomodulatory Cereblon E3 Ligase Modulators (CELMoDs) offer the potential to overcome resistance to conventional immunomodulatory agents. Based upon PubMed and abstract searches primarily from the past 4 years, here we review the data supporting novel immunotherapies for R/R MM. Expert opinion Overcoming disease resistance remains a challenge in R/R MM. Novel therapeutic approaches targeting MM antigens and/or enhancing immune cell function offer the potential to prolong survival and are actively being investigated in clinical trials.
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UMass Chan Med Sch, UMass Mem Med Ctr, Dept Med, 55 Lake Ave North, Worcester, MA 01655 USAUMass Chan Med Sch, UMass Mem Med Ctr, Dept Med, 55 Lake Ave North, Worcester, MA 01655 USA
Tanenbaum, Benjamin
Miett, Timothy
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UMass Chan Med Sch, UMass Mem Med Ctr, Dept Med, 55 Lake Ave North, Worcester, MA 01655 USAUMass Chan Med Sch, UMass Mem Med Ctr, Dept Med, 55 Lake Ave North, Worcester, MA 01655 USA
Miett, Timothy
Patel, Shyam A.
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UMass Chan Med Sch, UMass Mem Med Ctr, Dept Med, Div Hematol Oncol, 55 Lake Ave North, Worcester, MA 01655 USA
UMass Chan Med Sch, Ctr Clin & Translat Sci CCTS, 55 Lake Ave North, Worcester, MA 01655 USAUMass Chan Med Sch, UMass Mem Med Ctr, Dept Med, 55 Lake Ave North, Worcester, MA 01655 USA
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Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
Chim, C. S.
Kumar, S. K.
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Mayo Clin, Dept Med, Rochester, MN USAUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
Kumar, S. K.
Orlowski, R. Z.
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Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Div Canc Med, Houston, TX USAUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
Orlowski, R. Z.
Cook, G.
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Univ Leeds, Leeds Inst Canc & Pathol, Sect Expt Haematol, Haematol & Myeloma Studies, Leeds, W Yorkshire, EnglandUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
Cook, G.
Richardson, P. G.
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Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USAUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
Richardson, P. G.
Gertz, M. A.
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Mayo Clin, Dept Med, Rochester, MN USAUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
Gertz, M. A.
Giralt, S.
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Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USAUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
Giralt, S.
Mateos, M. V.
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Univ Hosp Salamanca, Dept Haematol, Salamanca, SpainUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
Mateos, M. V.
Leleu, X.
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Acad Hosp Poitiers CHU, Hop Mileterie, Poitiers, FranceUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
Leleu, X.
Anderson, K. C.
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Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USAUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
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Chinese Acad Sci, Hangzhou Inst Med HIM, Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
Wenzhou Med Univ, Wenzhou 325035, Zhejiang, Peoples R ChinaChinese Acad Sci, Hangzhou Inst Med HIM, Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
Chen, Qi
Zhang, Min
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Chinese Acad Sci, Hangzhou Inst Med HIM, Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
Wenzhou Med Univ, Wenzhou 325035, Zhejiang, Peoples R ChinaChinese Acad Sci, Hangzhou Inst Med HIM, Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
Zhang, Min
Zheng, Shan
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Chinese Acad Sci, Hangzhou Inst Med HIM, Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
Wenzhou Med Univ, Wenzhou 325035, Zhejiang, Peoples R ChinaChinese Acad Sci, Hangzhou Inst Med HIM, Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
Zheng, Shan
Tong, Yuxin
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Chinese Acad Sci, Hangzhou Inst Med HIM, Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
Wenzhou Med Univ, Wenzhou 325035, Zhejiang, Peoples R ChinaChinese Acad Sci, Hangzhou Inst Med HIM, Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
Tong, Yuxin
Tan, Yamin
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Chinese Acad Sci, Hangzhou Inst Med HIM, Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
Wenzhou Med Univ, Wenzhou 325035, Zhejiang, Peoples R ChinaChinese Acad Sci, Hangzhou Inst Med HIM, Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
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Univ Toronto, Princess Margaret Canc Ctr, Div Med Oncol & Hematol, Dept Med, Toronto, ON M5G 2C1, CanadaUniv Toronto, Princess Margaret Canc Ctr, Div Med Oncol & Hematol, Dept Med, Toronto, ON M5G 2C1, Canada
Sheikh, Semira
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Lebel, Eyal
Trudel, Suzanne
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Univ Toronto, Princess Margaret Canc Ctr, Div Med Oncol & Hematol, Dept Med, Toronto, ON M5G 2C1, CanadaUniv Toronto, Princess Margaret Canc Ctr, Div Med Oncol & Hematol, Dept Med, Toronto, ON M5G 2C1, Canada
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Univ Hosp Krems, Dept Internal Med 2, Mitterweg 10, A-3500 Krems An Der Donau, Austria
Karl Landsteiner Univ Hlth Sci, Mol Oncol & Hematol Unit, Dr Karl Dorrek Str 30, A-3500 Krems An Der Donau, AustriaUniv Hosp Krems, Dept Internal Med 2, Mitterweg 10, A-3500 Krems An Der Donau, Austria
Podar, Klaus
Leleu, Xavier
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Univ Poitiers Hosp, Dept Hematol, 2 Rue Miletrie, F-86021 Poitiers, France
Univ Poitiers Hosp, CIC1402 INSERM Unit, 2 Rue Miletrie, F-86021 Poitiers, FranceUniv Hosp Krems, Dept Internal Med 2, Mitterweg 10, A-3500 Krems An Der Donau, Austria