Recent advances in the development of nanomedicines for the treatment of ischemic stroke

被引：70

作者：

Tian, Xing ^{[1
]}

Fan, Taojian ^{[2
]}

Zhao, Wentian ^{[1
]}

Abbas, Ghulam ^{[2
]}

Han, Bo ^{[1
]}

Zhang, Ke ^{[1
]}

Li, Nan ^{[2
]}

Liu, Ning ^{[2
]}

Liang, Weiyuan ^{[2
]}

Huang, Hao ^{[2
]}

Chen, Wen ^{[1
]}

Wang, Bing ^{[2
]}

Xie, Zhongjian ^{[3
]}

机构：

[1] Shihezi Univ, Coll Pharm, Key Lab Xinjiang Phytomed Resource & Utilizat, Minist Educ, Shihezi 832002, Peoples R China

[2] Shenzhen Univ, Coll Phys & Optoelect Engn,Shenzhen Key Lab Micro, Collaborat Innovat Ctr Optoelect Sci & Technol,Mi, Inst Microscale Optoelect,Key Lab Optoelect Devic, Shenzhen 518060, Peoples R China

[3] Shenzhen Int Inst Biomed Res, Shenzhen 518116, Guangdong, Peoples R China

来源：

BIOACTIVE MATERIALS | 2021年 / 6卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Stroke; Nanomaterials; Blood-brain barrier; IRON-OXIDE NANOPARTICLES; SURFACE-PLASMON RESONANCE; MULTILAYER BLACK PHOSPHORUS; NONLINEAR-OPTICAL RESPONSE; WALLED CARBON NANOTUBES; NEURAL STEM-CELLS; IN-VIVO; DRUG-DELIVERY; GOLD NANOPARTICLES; GRAPHENE OXIDE;

D O I：

10.1016/j.bioactmat.2021.01.023

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Ischemic stroke is still a serious threat to human life and health, but there are few therapeutic options available to treat stroke because of limited blood-brain penetration. The development of nanotechnology may overcome some of the problems related to traditional drug development. In this review, we focus on the potential applications of nanotechnology in stroke. First, we will discuss the main molecular pathological mechanisms of ischemic stroke to develop a targeted strategy. Second, considering the important role of the blood-brain barrier in stroke treatment, we also delve mechanisms by which the blood-brain barrier protects the brain, and the reasons why the therapeutics must pass through the blood-brain barrier to achieve efficacy. Lastly, we provide a comprehensive review related to the application of nanomaterials to treat stroke, including liposomes, polymers, metal nanoparticles, carbon nanotubes, graphene, black phosphorus, hydmgels and dendrimers. To conclude, we will summarize the challenges and future prospects of nanomedicine-based stroke treatments.

引用

页码：2854 / 2869

页数：16

共 272 条

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