Synthetic antibiofilm peptides

被引：169
作者：
de la Fuente-Nunez, Cesar [1 ,5 ,6 ]
Cardoso, Marlon Henrique [2 ,3 ]
Candido, Elizabete de Souza [3 ,4 ]
Franco, Octavio Luiz [2 ,3 ,4 ]
Hancock, Robert E. W. [1 ]
机构：
[1] Univ British Columbia, Dept Microbiol & Immunol, Ctr Microbial Dis & Immun Res, Vancouver, BC V5Z 1M9, Canada
[2] Univ Brasilia, Dept Patol Mol, Brasilia, DF, Brazil
[3] Univ Catolica Brasilia, Ctr Anal Prote & Bioquim, Brasilia, DF, Brazil
[4] Univ Catolica Dom Bosco, S Inova Biotech, Programa Pos Grad Biotecnol, Campo Grande, MS, Brazil
[5] MIT, Dept Elect Engn & Comp Sci, Dept Biol Engn, Synthet Biol Grp,MIT Synthet Biol Ctr,Res Lab Ele, Cambridge, MA 02139 USA
[6] Broad Inst MIT & Harvard Univ, Cambridge, MA USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2016年 / 1858卷 / 05期
关键词：
Biofilms; Synthetic peptides; Persistent infections; Synergy; Antibiotic resistance; Biomaterials; RESISTANT STAPHYLOCOCCUS-AUREUS; BACTERIAL BIOFILM FORMATION; PSEUDOMONAS-AERUGINOSA-BIOFILMS; ANTIMICROBIAL CATIONIC PEPTIDES; IMPLANT-ASSOCIATED INFECTIONS; IN-VITRO; PERSISTER CELLS; BROAD-SPECTRUM; LOCAL-DELIVERY; LL-37;
D O I：
10.1016/j.bbamem.2015.12.015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bacteria predominantly exist as multicellular aggregates known as biofilms that are associated with at least two thirds of all infections and exhibit increased adaptive resistance to conventional antibiotic therapies. Therefore, biofilms are major contributors to the global health problem of antibiotic resistance, and novel approaches to counter them are urgently needed. Small molecules of the innate immune system called host defense peptides (HDPs) have emerged as promising templates for the design of potent, broad-spectrum antibiofilm agents. Here, we review recent developments in the new field of synthetic antibiofilm peptides, including mechanistic insights, synergistic interactions with available antibiotics, and their potential as novel antimicrobials against persistent infections caused by biofilms. This article is part of a Special Issue entitled: Antimicrobial peptides edited by Karl Lohner and Kai Hilpert. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：1061 / 1069
页数：9
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