Distribution of CD4+CD8+ double positive T cells in a mouse model of allergic asthma

被引：3

作者：

Zuska-Prot, M. ^{[1
]}

Ziolkowski, H. ^{[1
]}

Jaroszewski, J. J. ^{[1
]}

Maslanka, T. ^{[1
]}

机构：

[1] Univ Warmia & Mazury, Dept Pharmacol & Toxicol, Fac Vet Med, Oczapowskiego 13, PL-10718 Olsztyn, Poland

来源：

POLISH JOURNAL OF VETERINARY SCIENCES | 2016年 / 19卷 / 01期

关键词：

CD4(+)CD8(+) double-positive (DP) T cells; asthma; MLNs; HNLNs; lungs;

D O I：

10.1515/pjvs-2016-0026

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The present study describes the distribution of CD4(+)CD8(+) double-positive (DP) T cells in various immune compartments of mice with ovalbumin (OVA)-induced allergic asthma. It was found that the absolute number of DP T cells was considerably increased in the mediastinal lymph nodes and lungs of asthmatic mice as compared with that determined in the healthy subjects. On the contrary, the absolute counts of DP T cells was significantly decreased in the head and neck lymph nodes, and in peripheral blood of OVA-immunized mice. These results suggest that DP T cells may be involved in the pathogenesis of allergic asthma.

引用

页码：217 / 219

页数：3

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