Melanin-concentrating hormone signaling systems in fish

被引：53

作者：

Kawauchi, H ^{[1
]}

Baker, BI

机构：

[1] Kitasato Univ, Sch Fisheries Sci, Mol Endocrinol Lab, Ofunato, Iwate 0220101, Japan

[2] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

来源：

PEPTIDES | 2004年 / 25卷 / 10期

基金：

日本学术振兴会;

关键词：

melanin-concentrating hormone (MCH); MCH receptor (MCH-R); gene expression; food intake signaling; orexigenic peptide; melanotropic signaling; alpha-melanophore stimulating hormone (alpha-MSH); melanocortin;

D O I：

10.1016/j.peptides.2004.03.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Melanin-concentrating hormone (MCH) is a cyclic neuropeptide synthesized as a preprohormone in the hypothalamus of all vertebrates. This neuropeptide binds to G-protein-coupled seven transmembrane receptor(s) to mediate its function. MCH was named after its function in teleosts, in which it causes aggregation or concentration of melanin granules in melanophores, thus regulating body color. The function of central MCH that has attracted most attention is its involvement in regulating food intake and energy homeostasis in mammals, a role confirmed through a series of experiments, including central administration of MCH or MCH receptor blockers, and genetic manipulation of MCH and its receptors. The aim of this article is to review the recent data on MCH and MCH receptor signaling systems in fish. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1577 / 1584

页数：8

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