Bioactive compounds from herbal medicines to manage dyslipidemia

被引：51
作者：
Ji, Xinyu [1 ]
Shi, Shuai [2 ]
Liu, Bin [1 ]
Shan, Mingxu [3 ]
Tang, Danli [4 ]
Zhang, Wantong [5 ]
Zhang, Yin [1 ,6 ]
Zhang, Lulu [1 ,6 ]
Zhang, Huamin [7 ]
Lu, Cheng [1 ]
Wang, Yongyan [1 ]
机构：
[1] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China
[2] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing 100053, Peoples R China
[3] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing Key Lab Qual Evalut Tradit Chinese Med, Beijing 100102, Peoples R China
[4] China Acad Chinese Med Sci, Expt Res Ctr, Beijing 100700, Peoples R China
[5] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing 100091, Peoples R China
[6] Yichun Univ, Key Lab Res Act Ingredients Nat Med Jiangxi Prov, Yichun 336000, Peoples R China
[7] China Acad Chinese Med Sci, Inst Informat Tradit Chinese Med, Beijing 100700, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2019年 / 118卷
关键词：
Dyslipidemia; Herbal medicine; Underlying mechanisms; Bioactive; Compounds; TRIGLYCERIDE TRANSFER PROTEIN; APOLIPOPROTEIN-B SECRETION; ESTER TRANSFER PROTEIN; PICK C1-LIKE 1; FOAM CELL-FORMATION; CHOLESTEROL EFFLUX; LIPID-ACCUMULATION; GENE-EXPRESSION; DENSITY-LIPOPROTEIN; HEPG2; CELLS;
D O I：
10.1016/j.biopha.2019.109338
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Dyslipidemia is a key risk factor for cardiovascular diseases, which are a major cause of morbidity and mortality worldwide. However, despite the advancement of the treatment and prevention of dyslipidemia, medications used to treat dyslipidemia are limited to chemical drugs. Herbal medicine, as an alternative treatment, has a long history of usage and provides more treatment options, and related studies have revealed intervention targets for dyslipidemia. Four lipid-lowering mechanisms of herbal medicines have been proposed and are discussed in this paper. These mechanisms are the inhibition of cholesterol absorption in enterocytes, reduction of cholesterol synthesis, elevation of reverse cholesterol transport, and promotion of cholesterol excretion in the liver. This review elaborates on the underlying molecular pathways involved in plasma lipid balance via bioactive compounds from herbal medicines.
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页数：12
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