Preparation, characterization and tableting properties of two new pachyman-based pharmaceutical aids: I. disintegrants in dispersible tablets

被引：12

作者：

Xiao, Yuling

Liang, Shucai

Qiu, Guofu

Wu, Jianyuan

Zhang, Junbo

Hu, Xianming ^{[1
]}

机构：

[1] Wuhan Univ, Coll Pharm, Wuhan 430072, Peoples R China

[2] Wuhan Univ, ZhongNan Hosp, Wuhan 430072, Peoples R China

来源：

POLYMERS FOR ADVANCED TECHNOLOGIES | 2007年 / 18卷 / 04期

关键词：

linear; pachyman derivatives; hydrophilic polymers; disintegrant; biocompatibility;

D O I：

10.1002/pat.849

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Linear pachyman was isolated from the sclerotium of Poria cocos. Its hydroxypropyl and carboxymethyl derivatives, with considerable hydrophilicities, were synthesized. Their chemical structures, biocompatibilities, powder and tableting properties were determined. To exploit their novel applications in tablet excipients, ampicillin and probenecid dispersible tablets were compressed using the two derivatives as disintegrants, respectively. The detailed characterization of the tablets indicated the great potential of the two synthesized derivatives to be used as pharmaceutical excipients. Copyright (C) 2007 John Wiley & Sons, Ltd.

引用

页码：268 / 274

页数：7

共 17 条

[1] Antiproliferative and differentiating effects of polysaccharide fraction from fu-ling (Poria cocos) on human leukemic U937 and HL-60 cells [J].