Use of Myocardial T1 Mapping at 3.0 T to Differentiate Anderson-Fabry Disease from Hypertrophic Cardiomyopathy

被引：62

作者：

Karur, Gauri R. ^{[1
]}

Robison, Sean ^{[1
]}

Iwanochko, Robert M. ^{[2
]}

Morel, Chantal F. ^{[3
,4
]}

Crean, Andrew M. ^{[2
]}

Thavendiranathan, Paaladinesh ^{[1
,2
]}

Nguyen, Elsie T. ^{[1
]}

Mathur, Shobhit ^{[1
]}

Wasim, Syed ^{[3
,4
]}

Hanneman, Kate ^{[1
]}

机构：

[1] Univ Toronto, Toronto Joint Dept Med Imaging, Toronto Gen Hosp, 585 Univ Ave,1 PMB 298, Toronto, ON M5G 2N2, Canada

[2] Univ Toronto, Univ Hlth Network, Div Cardiol, Peter Munk Cardiac Ctr, Toronto, ON, Canada

[3] Univ Hlth Network, Fred A Litwin Ctr Genet Med, Toronto, ON, Canada

[4] Univ Toronto, Mt Sinai Hosp, Toronto, ON, Canada

来源：

RADIOLOGY | 2018年 / 288卷 / 02期

基金：

加拿大健康研究院;

关键词：

CARDIOVASCULAR MAGNETIC-RESONANCE; ENZYME REPLACEMENT THERAPY; EXTRACELLULAR VOLUME; HEART; ALPHA;

D O I：

10.1148/radiol.2018172613

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To compare left ventricular (LV) and right ventricular (RV) 3.0-T cardiac magnetic resonance (MR) imaging T1 values in Anderson-Fabry disease (AFD) and hypertrophic cardiomyopathy (HCM) and evaluate the diagnostic value of native T1 values beyond age, sex, and conventional imaging features. Materials and Methods: For this prospective study, 30 patients with gene-positive AFD (37% male; mean age +/- standard deviation, 45.0 years +/- 14.1) and 30 patients with HCM (57% male; mean age, 49.3 years +/- 13.5) were prospectively recruited between June 2016 and September 2017 to undergo cardiac MR imaging T1 mapping with a modified Look-Locker inversion recovery (MOLLI) acquisition scheme at 3.0 T (repetition time msec/echo time msec, 280/1.12; section thickness, 8 mm). LV and RV T1 values were evaluated. Statistical analysis included independent samples t test, receiver operating characteristic curve analysis, multi-variable logistic regression, and likelihood ratio test. Results: Septal LV, global LV, and RV native T1 values were significantly lower in AFD compared with those in HCM (1161 msec 6 47 vs 1296 msec +/- 55, respectively [P < .001]; 1192 msec +/- 52 vs 1268 msec +/- 55 [P < .001]; and 1221 msec +/- 54 vs 1271 msec +/- 37 [P =.001], respectively). A septal LV native T1 cutoff point of 1220 msec or lower distinguished AFD from HCM with sensitivity of 97%, specificity of 93%, and accuracy of 95%. Septal LV native T1 values differentiated AFD from HCM after adjustment for age, sex, and conventional imaging features (odds ratio, 0.94; 95% confidence interval: 0.91, 0.98; P < .001). In a nested logistic regression model with age, sex, and conventional imaging features, model fit was significantly improved by the addition of septal LV native T1 values (chi(2) [df = 1] = 33.4; P < .001). Conclusion: Cardiac MR imaging native T1 values at 3.0 T are significantly lower in patients with AFD compared with those with HCM and provide independent and incremental diagnostic value beyond age, sex, and conventional imaging features. (c) RSNA, 2018

引用

页码：398 / 406

页数：9

共 31 条

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