First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing β-lactamase

被引：247

作者：

Villegas, Maria Virginia

Lolans, Karen

Correa, Adriana

Kattan, Juan Nicolas

Lopez, Jaime A.

Quinn, John P.

机构：

[1] CIDEIM, Int Ctr Med Res & Training, Cali, Colombia

[2] John Stroger Hosp, Chicago, IL USA

[3] Chicago Infect Dis Res Inst, Chicago, IL USA

[4] Hosp Pablo Tobon Uribe, Medellin, Colombia

[5] Rush Univ, Med Ctr, Chicago, IL 60612 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 04期

关键词：

D O I：

10.1128/AAC.01405-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In Medellin, Colombia, three Pseudomonas aeruginosa isolates with high-level carbapenem resistance (MIC >= 256 mu g/ml) and an isolate of Citrobacter freundii with reduced susceptibility to imipenem produced the plasmid-mediated class A carbapenemase KPC-2. This is the first report of a KPC-type beta-lactamase identified outside of the family Enterobacteriaceae.

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页码：1553 / 1555

页数：3

相关论文

共 27 条

[1]

[Anonymous], M7A6 CLSI

[2] Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa [J].

Bonomo, Robert A. ;

Szabo, Dora .

CLINICAL INFECTIOUS DISEASES, 2006, 43 :S49-S56

[3] Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 β-lactamases in New York City [J].

Bradford, PA ;

Bratu, S ;

Urban, C ;

Visalli, M ;

Mariano, N ;

Landman, D ;

Rahal, JJ ;

Brooks, S ;

Cebular, S ;

Quale, J .

CLINICAL INFECTIOUS DISEASES, 2004, 39 (01) :55-60

[4] Detection of KPC carbapenem-hydrolyzing enzymes in Enterobacter spp. from Brooklyn, New York [J].

Bratu, S ;

Landman, D ;

Alam, M ;

Tolentino, E ;

Quale, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (02) :776-778

[5] Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-8, a novel metallo-β-lactamase, in a tertiary care center in Cali, Colombia [J].

Crespo, MP ;

Woodford, N ;

Sinclair, A ;

Kaufmann, ME ;

Turton, J ;

Glover, J ;

Velez, JD ;

Castañeda, CR ;

Recalde, M ;

Livermore, DM .

JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (11) :5094-5101

[6] Emergence of serine carbapenemases (KPC and SME) among clinical strains of Enterobacteriaceae isolated in the United States Medical Centers: Report from the MYSTIC Program (1999-2005) [J].

Deshpande, Lalitagauri M. ;

Rhomberg, Paul R. ;

Sader, Helio S. ;

Jones, Ronald N. .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2006, 56 (04) :367-372

[7] Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 in an Enterobacter sp. [J].

Hossain, A ;

Ferraro, MJ ;

Pino, RM ;

Dew, RB ;

Moland, ES ;

Lockhart, TJ ;

Thomson, KS ;

Goering, RV ;

Hanson, ND .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (11) :4438-4440

[8] Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa:: Our worst nightmare? [J].

Livermore, DM .

CLINICAL INFECTIOUS DISEASES, 2002, 34 (05) :634-640

[9] Multicity outbreak of carbapenem-resistant Acinetobacter baumannii isolates producing the carbapenemase OXA-40 [J].

Lolans, Karen ;

Rice, Thomas W. ;

Munoz-Price, L. Silvia ;

Quinn, John P. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (09) :2941-2945

[10] USE OF ANALYTICAL ISOELECTRIC FOCUSING FOR DETECTION AND IDENTIFICATION OF BETA-LACTAMASES [J].

MATTHEW, M ;

HARRIS, AM ;

MARSHALL, MJ ;

ROSS, GW .

JOURNAL OF GENERAL MICROBIOLOGY, 1975, 88 (MAY) :169-178