Common variants near TERC are associated with mean telomere length

被引：275

作者：

Codd, Veryan ^{[1
]}

Mangino, Massimo ^{[2
]}

van der Harst, Pim ^{[1
,3
]}

Braund, Peter S. ^{[1
]}

Kaiser, Michael ^{[1
]}

Beveridge, Alan J. ^{[1
]}

Rafelt, Suzanne ^{[1
]}

Moore, Jasbir ^{[1
]}

Nelson, Chris ^{[1
]}

Soranzo, Nicole ^{[2
,4
]}

Zhai, Guangju ^{[2
]}

Valdes, Ana M. ^{[2
]}

Blackburn, Hannah ^{[4
]}

Leach, Irene Mateo ^{[3
]}

de Boer, Rudolf A. ^{[3
]}

Goodall, Alison H. ^{[1
]}

Ouwehand, Willem ^{[5
]}

van Veldhuisen, Dirk J. ^{[3
]}

van Gilst, Wiek H. ^{[3
]}

Navis, Gerjan ^{[6
]}

Burton, Paul R. ^{[7
,8
]}

Tobin, Martin D. ^{[7
,8
]}

Hall, Alistair S. ^{[9
]}

Thompson, John R. ^{[7
,8
]}

Spector, Tim ^{[2
]}

Samani, Nilesh J. ^{[1
]}

机构：

[1] Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, Leicester, Leics, England

[2] Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands

[4] Wellcome Trust Sanger Inst, Hinxton, England

[5] Univ Cambridge, Dept Hematol, Cambridge, England

[6] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands

[7] Univ Leicester, Dept Hlth Sci, Leicester, Leics, England

[8] Univ Leicester, Dept Genet, Leicester, Leics, England

[9] Univ Leeds, Leeds Inst Genet Hlth & Therapeut, Leeds, W Yorkshire, England

来源：

NATURE GENETICS | 2010年 / 42卷 / 03期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

GENOME-WIDE ASSOCIATION; LEUCINE-RICH REPEAT; GENERAL-POPULATION; HUMANS; LOCUS;

D O I：

10.1038/ng.532

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an similar to 75-base-pair reduction in mean telomere length, equivalent to similar to 3.6 years of age-related telomere-length attrition.

引用

页码：197 / 199

页数：3

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