Neuroendocrine metastatic tumors of the liver resembling hepatocellular carcinoma

Certain ineuroendocrine tumors NET) metastasized to the liver can resemble hepatocendlar carcinoma (MCC) un cytdlogical needlebiopsy. Experience concerning the histdlogic Characteristics of Imetastatic NEW iresembling IHCC in core needle hepatic biopsies has been scarce Trifle aim of this study is to describe the his"cilogical criteria in seven metastatic INET that iresembled IHOC in core needle Ihepatic biopsy. From a total of 285 needle biopsies With primary tor metastasized hepatic neoplasms, seven cases were selected Tingly diagnosed as HOC or IHOC vs. NET imetastasized to the Inver. Fourteen needle biopsies of hepatocenalarIcarbinomas were also studied or comparativepurposes. In all of these IneoPlasms the diagnosis of endocrine tumor was confirmed by immuncihisto Chemical studies and the.fdllowing iinformation was recorded age sex, radiotogical alterations primary site of the INET, and Elow-mp. The receiving infrastructure data were also recorded fibrotic stroma associated or licit With the ineoplastic cells growth pattern form of the cells, cellular size, imitotic figures, inkleornegaly apparent InuClecilii, Chromatin in salt and pepper, Hilasmacytoid cells, intranudear inClusions and binary pigment. In conclusion these characteristics were common in metastasized neuroendocrine tumors extensive quomat fibrosis, Su.ght to moderate atypia hyperchromatic nucler iplasmacytoid cells, and thin delicate strands of fibrovasoulartissue supporting larger iacinar groups of net cells. HOC had a more infrequent.fibrotic Strorria moderate to marked aitypia, and lin some biopsies binary pigment, intranuclear inclusions, and cells