Immunostimulating effects of a sulfated galactan from Codium fragile

被引：67

作者：

Lee, Jung-Bum ^{[1
]}

Ohta, Yuko ^{[1
]}

Hayashi, Kyoko ^{[1
]}

Hayashi, Toshimitsu ^{[1
]}

机构：

[1] Toyama Univ, Grad Sch Med & Pharmaceut Sci Res, Toyama 9300194, Japan

来源：

CARBOHYDRATE RESEARCH | 2010年 / 345卷 / 10期

关键词：

Pyruvylated sulfated galactan; Codium fragile; Immunostimulating effect; RAW; 264.7; cells; RHAMNAN SULFATE; MONOSTROMA-LATISSIMUM; ANTIVIRAL ACTIVITIES; CELL-WALLS; POLYSACCHARIDES; ALGAE;

D O I：

10.1016/j.carres.2010.02.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A pyruvylated sulfated galactan from Codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal D-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. This particular polysaccharide was found to stimulate the production of nitric oxide by inducing iNOS at the mRNA and protein levels. In addition, the polysaccharide also induced several cytokine mRNA expressions such as IL-1 beta, IL-6, IL-10 and TNF-alpha. Therefore, it appears that the sulfated galactan might possess the immunostimulating effects via activation of macrophages. (c) 2010 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1452 / 1454

页数：3

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