Biocompatibility and toxicity of graphene quantum dots for potential application in photodynamic therapy

被引：169

作者：

Tabish, Tanveer A. ^{[1
]}

Scotton, Chris J. ^{[2
]}

Ferguson, Daniel C. J. ^{[2
]}

Lin, Liangxu ^{[1
]}

van der Veen, Anienke ^{[2
]}

Lowry, Sophie ^{[2
]}

Ali, Muhammad ^{[3
,4
]}

Jabeen, Farhat ^{[3
]}

Winyard, Paul G. ^{[2
]}

Zhang, Shaowei ^{[1
]}

机构：

[1] Univ Exeter, Coll Engn Math & Phys Sci, Ctr Graphene Sci, Stocker Rd, Exeter EX4 4QF, Devon, England

[2] Univ Exeter, Inst Biomed & Clin Sci, Med Sch, St Lukes Campus, Exeter EX1 2LU, Devon, England

[3] Govt Coll Univ, Dept Zool, Faisalabad 38000, Pakistan

[4] Bahauddin Zakariya Univ, Fac Anim Sci, Multan 60800, Pakistan

来源：

NANOMEDICINE | 2018年 / 13卷 / 15期

基金：

英国工程与自然科学研究理事会;

关键词：

biocompatibility; corrosion resistance; graphene quantum dots; photodynamic therapy; photostability; reactive oxygen species; singlet oxygen; toxicity; BIOMEDICAL APPLICATIONS; SINGLET OXYGEN; PHOTOLUMINESCENCE; OXIDE; SIZE; NANOTECHNOLOGY; NANOPARTICLES; NANOMATERIALS; REDUCTION; SULFUR;

D O I：

10.2217/nnm-2018-0018

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: Achieving reliably high production of reactive oxygen species (ROS) in photodynamic therapy (PDT) remains challenging. Graphene quantum dots (GQDs) hold great promise for PDT. However, the photo-chemical processes leading to GQD-derived ROS generation have not yet been fully elucidated. Materials & methods: Physicochemical characteristics of GQDs were comprehensively investigated, including electron paramagnetic resonance analysis of singlet oxygen production. Dark toxicity was assessed in vitro and in vivo. Results: GQDs demonstrated excellent photoluminescent features, corrosion resistance, high water solubility, high photo/pH-stability, in vitro and in vivo biocompatibility and very efficient singlet oxygen/ROS generation. Conclusion: The enhanced ROS generation, combined with good biocompatibility and minimal toxicity in vitro and in vivo support the potential of GQDs for future PDT application.

引用

页码：1923 / 1937

页数：15

共 65 条

[1] Quantum dots as photosensitizers?
Bakalova, R
Ohba, H
Zhelev, Z
Ishikawa, M
Baba, Y
[J]. NATURE BIOTECHNOLOGY, 2004, 22 (11) : 1360 - 1361
[2] Investigation of processing effects on the corrosion resistance of Ti20Mo alloy in saline solutions
Bolat, G.
Izquierdo, J.
Gloriant, T.
Chelariu, R.
Mareci, D.
Souto, R. M.
[J]. CORROSION SCIENCE, 2015, 98 : 170 - 179
[3] Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects
Cai, WB
Shin, DW
Chen, K
Gheysens, O
Cao, QZ
Wang, SX
Gambhir, SS
Chen, XY
[J]. NANO LETTERS, 2006, 6 (04) : 669 - 676
[4] Photodynamic therapy and anti-tumour immunity
Castano, Ana P.
Mroz, Pawel
Hamblin, Michael R.
[J]. NATURE REVIEWS CANCER, 2006, 6 (07) : 535 - 545
[5] Upconverting nanoparticles as nanotransducers for photodynamic therapy in cancer cells
Chatterjee, Dev K.
Yong, Zhang
[J]. NANOMEDICINE, 2008, 3 (01) : 73 - 82
[6] Chemical Reduction of Graphene Oxide to Graphene by Sulfur-Containing Compounds
Chen, Wufeng
Yan, Lifeng
Bangal, P. R.
[J]. JOURNAL OF PHYSICAL CHEMISTRY C, 2010, 114 (47) : 19885 - 19890
[7] Renal clearance of quantum dots
Choi, Hak Soo
Liu, Wenhao
Misra, Preeti
Tanaka, Eiichi
Zimmer, John P.
Ipe, Binil Itty
Bawendi, Moungi G.
Frangioni, John V.
[J]. NATURE BIOTECHNOLOGY, 2007, 25 (10) : 1165 - 1170
[8] Photodynamic Graphene Quantum Dot: Reduction Condition Regulated Photoactivity and Size Dependent Efficacy
Du, Dou
Wang, Kun
Wen, Ya
Li, Yan
Li, Yong Y.
[J]. ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (05) : 3287 - 3294
[9] Chemically doped fluorescent carbon and graphene quantum dots for bioimaging, sensor, catalytic and photoelectronic applications
Du, Yan
Guo, Shaojun
[J]. NANOSCALE, 2016, 8 (05) : 2532 - 2543
[10] Cancer nanotechnology: Opportunities and challenges
Ferrari, M
[J]. NATURE REVIEWS CANCER, 2005, 5 (03) : 161 - 171

← 1 2 3 4 5 6 7 →