Biocompatibility and toxicity of graphene quantum dots for potential application in photodynamic therapy

被引：172

作者：

Tabish, Tanveer A. ^{[1
]}

Scotton, Chris J. ^{[2
]}

Ferguson, Daniel C. J. ^{[2
]}

Lin, Liangxu ^{[1
]}

van der Veen, Anienke ^{[2
]}

Lowry, Sophie ^{[2
]}

Ali, Muhammad ^{[3
,4
]}

Jabeen, Farhat ^{[3
]}

Winyard, Paul G. ^{[2
]}

Zhang, Shaowei ^{[1
]}

机构：

[1] Univ Exeter, Coll Engn Math & Phys Sci, Ctr Graphene Sci, Stocker Rd, Exeter EX4 4QF, Devon, England

[2] Univ Exeter, Inst Biomed & Clin Sci, Med Sch, St Lukes Campus, Exeter EX1 2LU, Devon, England

[3] Govt Coll Univ, Dept Zool, Faisalabad 38000, Pakistan

[4] Bahauddin Zakariya Univ, Fac Anim Sci, Multan 60800, Pakistan

来源：

NANOMEDICINE | 2018年 / 13卷 / 15期

基金：

英国工程与自然科学研究理事会;

关键词：

biocompatibility; corrosion resistance; graphene quantum dots; photodynamic therapy; photostability; reactive oxygen species; singlet oxygen; toxicity; BIOMEDICAL APPLICATIONS; SINGLET OXYGEN; PHOTOLUMINESCENCE; OXIDE; SIZE; NANOTECHNOLOGY; NANOPARTICLES; NANOMATERIALS; REDUCTION; SULFUR;

D O I：

10.2217/nnm-2018-0018

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: Achieving reliably high production of reactive oxygen species (ROS) in photodynamic therapy (PDT) remains challenging. Graphene quantum dots (GQDs) hold great promise for PDT. However, the photo-chemical processes leading to GQD-derived ROS generation have not yet been fully elucidated. Materials & methods: Physicochemical characteristics of GQDs were comprehensively investigated, including electron paramagnetic resonance analysis of singlet oxygen production. Dark toxicity was assessed in vitro and in vivo. Results: GQDs demonstrated excellent photoluminescent features, corrosion resistance, high water solubility, high photo/pH-stability, in vitro and in vivo biocompatibility and very efficient singlet oxygen/ROS generation. Conclusion: The enhanced ROS generation, combined with good biocompatibility and minimal toxicity in vitro and in vivo support the potential of GQDs for future PDT application.

引用

页码：1923 / 1937

页数：15

共 65 条

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