Deconditioning in COVID-19 survivors with reduced exercise performance: A role for endothelial dysfunction?

被引：7

作者：

Ambrosino, Pasquale ^{[1
]}

Maniscaico, Mauro ^{[2
,3
]}

机构：

[1] Ist Clin Sci Maugeri IRCCS, Telese Terme Inst, Cardiac Rehabil Unit, Genoa, Italy

[2] Ist Clin Sci Maugeri IRCCS, Telese Terme Inst, Pulm Rehabil Unit, Genoa, Italy

[3] Univ Naples Federico II, Sect Resp Dis, Dept Clin Med & Surg, Naples, Italy

来源：

MEDICAL HYPOTHESES | 2022年 / 163卷

关键词：

COVID-19; Exercise; Rehabilitation; Disability; Outcome;

D O I：

10.1016/j.mehy.2022.110847

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Recent studies have reported an impaired exercise response at cardiopulmonary exercise testing (CPET) during convalescence from coronavirus disease 2019 (COVID-19). In detail, these previous reports suggest the presence of functional limitations in a consistent proportion of COVID-19 survivors, in the absence of relevant alterations of ventilatory and gas exchange parameters at CPET. Therefore, deconditioning has been proposed as the main mechanism of the reduced peak oxygen uptake in this clinical setting. This interpretation of the results is sup -ported by the evidence that deconditioning is a recognized aspect of the post-intensive care syndrome, with acute sarcopenia being frequently observed among COVID-19 survivors. Here, we hypothesized the role of endothelial dysfunction as a key pathogenic mechanism of the functional limitations of COVID-19, including multisystem deconditioning and subsequent exercise intolerance.

引用

页数：2

共 10 条

[1] Clinical Assessment of Endothelial Function in Convalescent COVID-19 Patients Undergoing Multidisciplinary Pulmonary Rehabilitation [J].

Ambrosino, Pasquale ;

Molino, Antonio ;

Calcaterra, Ilenia ;

Formisano, Roberto ;

Stufano, Silvia ;

Spedicato, Giorgio Alfredo ;

Motta, Andrea ;

Papa, Antimo ;

Di Minno, Matteo Nicola Dario ;

Maniscalco, Mauro .

BIOMEDICINES, 2021, 9 (06)

[2] Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020) [J].

Bai, Chunxue ;

Chotirmall, Sanjay H. ;

Rello, Jordi ;

Alba, George A. ;

Ginns, Leo C. ;

Krishnan, Jerry A. ;

Rogers, Robert ;

Bendstrup, Elisabeth ;

Burgel, Pierre-Regis ;

Chalmers, James D. ;

Chua, Abigail ;

Crothers, Kristina A. ;

Duggal, Abhijit ;

Kim, Yeon Wook ;

Laffey, John G. ;

Luna, Carlos M. ;

Niederman, Michael S. ;

Raghu, Ganesh ;

Ramirez, Julio A. ;

Riera, Jordi ;

Roca, Oriol ;

Tamae-Kakazu, Maximiliano ;

Torres, Antoni ;

Watkins, Richard R. ;

Barrecheguren, Miriam ;

Belliato, Mirko ;

Chami, Hassan A. ;

Chen, Rongchang ;

Cortes-Puentes, Gustavo A. ;

Delacruz, Charles ;

Hayes, Margaret M. ;

Heunks, Leo M. A. ;

Holets, Steven R. ;

Hough, Catherine L. ;

Jagpal, Sugeet ;

Jeon, Kyeongman ;

Johkoh, Takeshi ;

Lee, May M. ;

Liebler, Janice ;

McElvaney, Gerry N. ;

Moskowitz, Ari ;

Oeckler, Richard A. ;

Ojanguren, Inigo ;

O'Regan, Anthony ;

Pletz, Mathias W. ;

Rhee, Chin Kook ;

Schultz, Marcus J. ;

Storti, Enrico ;

Strange, Charlie ;

Thomson, Carey C. .

EUROPEAN RESPIRATORY REVIEW, 2020, 29 (157) :1-15

[3] WISE 2005: chronic bed rest impairs microcirculatory endothelium in women [J].

Demiot, Claire ;

Dignat-George, Francoise ;

Fortrat, Jacques-Olivier ;

Sabatier, Florence ;

Gharib, Claude ;

Larina, Irina ;

Gauquelin-Koch, Guillemette ;

Hughson, Richard ;

Custaud, Marc-Antoine .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 293 (05) :H3159-H3164

[4] Cardiopulmonary exercise testing might be helpful for interpretation of impaired pulmonary function in recovered COVID-19 patients [J].

Gao, Yi ;

Chen, Ruchong ;

Geng, Qian ;

Mo, Xiaoneng ;

Zhan, Chen ;

Jian, Wenhua ;

Li, Shiyue ;

Zheng, Jinping .

EUROPEAN RESPIRATORY JOURNAL, 2021, 57 (01)

[5] Management of post-acute covid-19 in primary care [J].

Greenhalgh, Trisha ;

Knight, Matthew ;

A'Court, Christine ;

Buxton, Maria ;

Husain, Laiba .

BMJ-BRITISH MEDICAL JOURNAL, 2020, 370

[6] Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase [J].

Hambrecht, R ;

Adams, V ;

Erbs, S ;

Linke, A ;

Kränkel, N ;

Shu, Y ;

Baither, Y ;

Gielen, S ;

Thiele, H ;

Gummert, JF ;

Mohr, FW ;

Schuler, G .

CIRCULATION, 2003, 107 (25) :3152-3158

[7] Exercise capacity impairment after COVID-19 pneumonia is mainly caused by deconditioning [J].

Jahn, Kathleen ;

Sava, Mihaela ;

Sommer, Gregor ;

Schumann, Desiree M. ;

Bassetti, Stefano ;

Siegemund, Martin ;

Battegay, Manuel ;

Stolz, Daiana ;

Tamm, Michael ;

Khanna, Nina ;

Hostettler, Katrin E. .

EUROPEAN RESPIRATORY JOURNAL, 2022, 59 (01)

[8] Post-COVID-19 acute sarcopenia: physiopathology and management [J].

Piotrowicz, Karolina ;

Gasowski, Jerzy ;

Michel, Jean-Pierre ;

Veronese, Nicola .

AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2021, 33 (10) :2887-2898

[9] Deconditioning as main mechanism of impaired exercise response in COVID-19 survivors [J].

Rinaldo, Rocco Francesco ;

Mondoni, Michele ;

Parazzini, Elena Maria ;

Pitari, Federica ;

Brambilla, Elena ;

Luraschi, Simone ;

Balbi, Maurizio ;

Papa, Giuseppe Francesco Sferrazza ;

Sotgiu, Giovanni ;

Guazzi, Marco ;

Marco, Fabiano Di ;

Centanni, Stefano .

EUROPEAN RESPIRATORY JOURNAL, 2021, 58 (02)

[10] Cardiopulmonary exercise capacity and limitations 3 months after COVID-19 hospitalisation [J].

Skjorten, Ingunn ;

Ankerstjerne, Odd Andre Wathne ;

Trebinjac, Divna ;

Bronstad, Eivind ;

Rasch-Halvorsen, Oystein ;

Einvik, Gunnar ;

Lerum, Tori Vigeland ;

Stavem, Knut ;

Edvardsen, Anne ;

Ingul, Charlotte Bjork .

EUROPEAN RESPIRATORY JOURNAL, 2021, 58 (02)

← 1 →