The Role of Humous Acids in Acqua di Fiuggi Mineral Water in Degrading Stones Formed in the Urinary Tract (Review)

被引：4
作者：
Davydova, N. K. [1 ]
Sergeev, V. N. [1 ]
Girbul, E. [2 ]
机构：
[1] Russian Acad Sci, AN Nesmeyanov Inst Elemental Organ Cpds, Moscow 11991, Russia
[2] ECOS ITALIA, I-03014 Fiuggi, Frosinone, Italy
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2014年 / 48卷 / 09期
关键词：
Humous acids; humic acids; fulvic acids; urinary stone disease; acqua di Fiuggi mineral water; SIZE-EXCLUSION CHROMATOGRAPHY; HUMIC SUBSTANCES; ANTICOLANA VALLEY;
D O I：
10.1007/s11094-014-1155-y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This review presents data on the high efficacy of acqua di Fiuggi water in the treatment and prophylaxis of urinary stone disease. Acqua di Fiuggi is a natural oligomineral water with a strong diuretic effect. Its contents include the humic substances with which the soil of the Anticolana valley is enriched. Humous substances, which are natural macromolecules with complex, disordered moleculare structures, include humic acids and fulvic acids, which are key components of acqua di Fiuggi. These acids can disorder the crystal lattices of calcium salts (oxalates, phosphates, etc.) in kidney stones, forming soluble calcium complexes. The result is that stones dissolve and are eliminated from the human body via the natural pathway.
引用
收藏
页码：587 / 592
页数：6
相关论文
共 24 条
[1]  
Alyaev Yu. G., 2012, FUNDAM ISSLED, V99, p186
[2]  
Avakumova N. P., 2009, IZV SAMARSK NAUCHIN, V11, p197
[3]   Effects of water hardness on urinary risk factors for kidney stones in patients with idiopathic nephrolithiasis [J].
Bellizzi, V ;
De Nicola, L ;
Minutolo, R ;
Russo, D ;
Cianciaruso, B ;
Andreucci, M ;
Conte, G ;
Andreucci, VE .
NEPHRON, 1999, 81 :66-70
[4]   Antihypoxic Activity of Native Humic Acids of Tomsk Lowland Peat [J].
Belousov, M. V. ;
Akhmedzhanov, R. R. ;
Zykova, M. V. ;
Arbuzov, A. N. ;
Gur'ev, A. M. ;
Yusubov, M. S. .
PHARMACEUTICAL CHEMISTRY JOURNAL, 2014, 48 (02) :97-99
[5]   Chemical analysis of water of the Anticolana Valley: Isolation of humic compounds [J].
Calace, N ;
D'Ascenzo, G ;
Curtis, SD ;
Delfini, M ;
Fraioli, A ;
Petronio, BM .
NEPHRON, 1999, 81 :93-97
[6]   High pressure size exclusion chromatography (HPSEC) of humic substances: Molecular sizes, analytical parameters, and column performance [J].
Conte, P ;
Piccolo, A .
CHEMOSPHERE, 1999, 38 (03) :517-528
[7]  
Curtis SD, 1999, NEPHRON, V81, P98
[8]   Stone recurrence after lithotripsy in patients with recurrent idiopathic calcium urolithiasis: Efficacy of treatment with Fiuggi water [J].
Di Silverio, F ;
Ricciuti, GP ;
D'Angelo, AR ;
Fraioli, A ;
Simeoni, G .
EUROPEAN UROLOGY, 2000, 37 (02) :145-148
[9]  
Evan A. P., UROLITHIASIS, DOI [10.1007/s00240-014-0701-02014, DOI 10.1007/S00240-014-0701-02014]
[10]  
Fraioli A, 2001, Clin Ter, V152, P347
123