Expression in hepatomas and chromosomal localization of rat protein phosphatase 5 gene

被引：1

作者：

Shirato, H

Shima, H

Nakagama, H

Fukuda, H

Watanabe, Y

Ogawa, K

Matsuda, Y

Kikuchi, K

机构：

[1] Hokkaido Univ, Inst Med Genet, Div Biochem Oncol & Immunol, Kita Ku, Sapporo, Hokkaido 0600815, Japan

[2] Natl Canc Ctr, Res Inst, Div Biochem, Chuo Ku, Tokyo 1040045, Japan

[3] Hokkaido Univ, Grad Sch Environm Earth Sci, Div Biosci, Lab Cytogenet,Kita Ku, Sapporo, Hokkaido 0600810, Japan

[4] Hokkaido Univ, Fac Sci, Chromosome Res Unit, Kita Ku, Sapporo, Hokkaido 0600810, Japan

[5] Asahikawa Med Coll, Dept Pathol 1, Asahikawa, Hokkaido 0788397, Japan

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2000年 / 17卷 / 05期

关键词：

PP5; hepatoma; regenerating liver; chromosomal mapping; protein phosphatase;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The serine/threonine protein phosphatase type 5 (PP5) gene expression was ubiquitously observed among all the tissues examined, but being at the lowest level in the liver. The levels of PP5 mRNA were markedly elevated in rat highly malignant ascites hepatomas, while those in several rat primary hepatomas were slightly increased and those in the regenerating livers were not elevated at all compared to the control liver. The PP5 gene was mapped to rat chromosome 1q22.1. This region has been identified to have linkage homology among human, mouse and rat, and is known to be associated with several tumor types. Taken together, the present results strongly suggest important roles of PP5 in tumorigenesis.

引用

页码：909 / 912

页数：4

共 29 条

[1] The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant
Chen, MS
Silverstein, AM
Pratt, WB
Chinkers, M
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (50) : 32315 - 32320
[2] A NOVEL HUMAN PROTEIN SERINE/THREONINE PHOSPHATASE, WHICH POSSESSES 4 TETRATRICOPEPTIDE REPEAT MOTIFS AND LOCALIZES TO THE NUCLEUS
CHEN, MX
MCPARTLIN, AE
BROWN, L
CHEN, YH
BARKER, HM
COHEN, PTW
[J]. EMBO JOURNAL, 1994, 13 (18) : 4278 - 4290
[3] Activation of protein phosphatase 5 by limited proteolysis or the binding of polyunsaturated fatty acids to the TPR domain
Chen, MX
Cohen, PTW
[J]. FEBS LETTERS, 1997, 400 (01): : 136 - 140
[4] Mapping of Ppp5c, the gene encoding protein phosphatase 5, to mouse Chromosome 7
Chinkers, M
[J]. MAMMALIAN GENOME, 1997, 8 (07) : 538 - 539
[5] TARGETING OF A DISTINCTIVE PROTEIN-SERINE PHOSPHATASE TO THE PROTEIN KINASE-LIKE DOMAIN OF THE ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR
CHINKERS, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (23) : 11075 - 11079
[6] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION
CHOMCZYNSKI, P
SACCHI, N
[J]. ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) : 156 - 159
[7] Novel protein serine/threonine phosphatases: Variety is the spice of life
Cohen, PTW
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (07) : 245 - 251
[8] Inhibition of protein serine threonine phosphatases by fumonisin B-1, a mycotoxin
Fukuda, H
Shima, H
Vesonder, RF
Tokuda, H
Nishino, H
Katoh, S
Tamura, S
Sugimura, T
Nagao, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 220 (01) : 160 - 165
[9] THE TPR SNAP HELIX - A NOVEL PROTEIN REPEAT MOTIF FROM MITOSIS TO TRANSCRIPTION
GOEBL, M
YANAGIDA, M
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1991, 16 (05) : 173 - 177
[10] EXPRESSION OF A CELLULAR ONCOGENE DURING LIVER-REGENERATION
GOYETTE, M
PETROPOULOS, CJ
SHANK, PR
FAUSTO, N
[J]. SCIENCE, 1983, 219 (4584) : 510 - 512

← 1 2 3 →