Markers of pancreatic cancer stem cells and their clinical and therapeutic implications

被引：96

作者：

Gzil, Arkadiusz ^{[1
]}

Zarebska, Izabela ^{[1
]}

Bursiewicz, Wiktor ^{[1
]}

Antosik, Paulina ^{[1
]}

Grzanka, Dariusz ^{[1
]}

Szylberg, Lukasz ^{[1
,2
]}

机构：

[1] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Clin Pathomorphol, Sklodowskiej Curie Str 9, PL-85094 Bydgoszcz, Poland

[2] Mil Clin Hosp, Dept Pathomorphol, Bydgoszcz, Poland

来源：

MOLECULAR BIOLOGY REPORTS | 2019年 / 46卷 / 06期

关键词：

Pancreatic cancer; Cancer stem cells; Prognostic factors; EPITHELIAL-MESENCHYMAL TRANSITION; P-GLYCOPROTEIN; HEMATOPOIETIC STEM; TUMOR-GROWTH; GEMCITABINE RESISTANCE; EXPRESSION PATTERNS; ACQUIRED-RESISTANCE; INCREASED SURVIVAL; ADJUVANT THERAPY; NANOG EXPRESSION;

D O I：

10.1007/s11033-019-05058-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pancreatic cancer (PC) is the fourth most common cause of death among all cancers. Poor prognosis of PC may be caused by a prevalence of cancer stem cells (CSCs). CSCs are a population of cancer cells showing stem cell-like characteristics. CSCs have the ability to self-renew and may initiate tumorigenesis. PC CSCs express markers such as CD133, CD24, CD44, DCLK1, CXCR4, ESA, Oct4 and ABCB1. There is a wide complexity of interaction and relationships between CSC markers in PC. These markers are negative prognostic factors and are connected with tumor recurrence and clinical progression. Additionally, PC CSCs are resistant to treatment with gemcitabine. Thus, most current therapies for PC are ineffective. Numerous studies have shown, that targeting of these proteins may increase both disease-free and overall survival in PC.

引用

页码：6629 / 6645

页数：17

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