Non-apoptogenic Ca2+-related extrusion of mitochondria in anoxia/reoxygenation stress

被引：7
作者：
Dorio, Annalisa
Cerella, Claudia
De Nicola, Milena
D'Alessio, Maria
Gualandi, Giampiero
Ghibelli, Lina
机构：
[1] Univ Roma Tor Vergata, Dipartimento Biol, I-00133 Rome, Italy
[2] Univ Tuscia, DABAC, I-01011 Viterbo, Italy
来源：
SODIUM-CALCIUM EXCHANGE AND THE PLASMA MEMBRANE CA2+-ATPASE IN CELL FUNCTION: FIFTH INTERNATIONAL CONFERENCE | 2007年 / 1099卷
关键词：
calcium; apoptosis; anoxia; reoxygenation; mitochondria;
D O I：
10.1196/annals.1387.067
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumor cells often develop molecular strategies for survival to anoxia/reoxygenation stress as part of tumor progression. Here we describe that the B lymphoma Epstein-Barr-positive cells E2r survive reoxygenation in spite of a very high and long-lasting increase in cytosolic Ca2+ and the loss of about half of their mitochondria due to specific extrusion of the organelles from the cells. The extrusion typically occurs 3 days after reoxygenation, and a regular mitochondrial asset is regained after further 24 h.
引用
收藏
页码：512 / 515
页数：4
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