Significance of Clonal Mutations in Bone Marrow Failure and Inherited Myelodysplastic Syndrome/Acute Myeloid Leukemia Predisposition Syndromes

被引：15

作者：

Schaefer, Eva J. ^{[1
]}

Lindsley, R. Coleman ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, 450 Brookline Ave, Boston, MA 02215 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2018年 / 32卷 / 04期

关键词：

Myelodysplastic syndrome; Bone marrow failure syndromes; Genetic predisposition; Clonal hematopoiesis; SEVERE CONGENITAL NEUTROPENIA; SHWACHMAN-DIAMOND SYNDROME; FANCONI-ANEMIA PATIENTS; HEMATOPOIETIC STEM; SOMATIC MUTATIONS; ASXL1; MUTATIONS; APLASTIC-ANEMIA; CSF3R MUTATIONS; GATA2; P53;

D O I：

10.1016/j.hoc.2018.03.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clonal hematopoiesis as a hallmark of myelodysplastic syndrome (MDS) is mediated by the selective advantage of clonal hematopoietic stem cells in a context-specific manner. Although primary MDS emerges without known predisposing cause and is associated with advanced age, secondary MDS may develop in younger patients with bone marrow failure syndromes or after exposure to chemotherapy. This article discusses recent advances in the understanding of context-dependent clonal hematopoiesis in MDS, with focus on clonal evolution in inherited and acquired bone marrow failure syndromes.

引用

页码：643 / +

页数：15

共 59 条

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