Effect of canine mesenchymal stromal cells loaded with paclitaxel on growth of canine glioma and human glioblastoma cell lines

被引：18
|
作者：
Bonomi, A. [1 ]
Ghezzi, E. [2 ]
Pascucci, L. [3 ]
Aralla, M. [2 ]
Ceserani, V. [4 ]
Pettinari, L. [2 ]
Cocce, V. [1 ]
Guercio, A. [5 ]
Alessandri, G. [4 ]
Parati, E. [4 ]
Brini, A. T. [1 ,6 ]
Zeira, O. [2 ]
Pessina, A. [1 ]
机构：
[1] Univ Milan, Dept Biomed Surg & Dent Sci, Via Pascal 36, I-20133 Milan, Italy
[2] Vet Hosp San Michele, Via 1 Maggio 37, I-26838 Lodi, Italy
[3] Univ Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, Italy
[4] IRCCS, Neurol Inst C Besta, Cellular Neurobiol Lab, Dept Cerebrovasc Dis, Via Celoria 11, I-20133 Milan, Italy
[5] Ist Zooprofilatt Sperimentale Sicilia A Mirri, Area Diagnost Virol, Palermo, Italy
[6] IRCCS, Galeazzi Orthopaed Inst, Milan, Italy
来源：
VETERINARY JOURNAL | 2017年 / 223卷
关键词：
Canine; Drug delivery; Glioma; Mesenchymal stromal cells; Paclitaxel; STEM-CELLS; IN-VITRO; ADIPOSE-TISSUE; EFFICACY; DELIVERY; VEHICLES; TUMORS;
D O I：
10.1016/j.tvjl.2017.05.005
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
This study investigated whether canine mesenchymal stromal cells (cMSCs) are able to take up and release paclitaxel (PTX) in active form, and therefore whether they have potential as a tool for therapeutic delivery of this drug. cMSCs from bone marrow and adipose tissue were isolated, expanded and characterised phenotypically. cMSCs were loaded with PTX (cMSCs-PTX) and their capacity for release of PTX was determined by their effect on proliferation of cancer cells. cMSCs-PTX derived from bone marrow and adipose tissue were able to take up and then release active PTX. cMSCs-PTC inhibited proliferation of the canine glioma cell line J3T, and the human glioblastoma cell lines T98G and U87MG. The potential of canine cMSCs-PTX for treatment of canine gliomas should be investigated further. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：45 / 51
页数：7
相关论文
共 50 条
  • [41] Canine amniotic membrane mesenchymal stromal/stem cells: Isolation, characterization and differentiation
    Borghesi, Jessica
    Lima, Mariana Ferreira
    Mario, Lara Carolina
    de Almeida da Anunciacao, Adriana Raquel
    Silveira Rabelo, Ana Carolina
    Kato Cano da Silva, Marcella Giancoli
    Fernandes, Fausto Assunpcao
    Miglino, Maria Angelica
    Oliveira Carreira, Ana Claudia
    Favaron, Phelipe Oliveira
    TISSUE & CELL, 2019, 58 : 99 - 106
  • [42] Human glioma cells-conditioned medium promotes proliferation and migration of human bone marrow mesenchymal stromal cells in vitro
    Zhu, Rusen
    Chen, Xinggui
    Li, Jinghong
    Lan, Liubo
    JOURNAL OF BUON, 2017, 22 (03): : 730 - 734
  • [43] Identification of two distinct mesenchymal stromal cell populations in human malignant glioma
    Svensson, Andreas
    Ramos-Moreno, Tania
    Eberstal, Sofia
    Scheding, Stefan
    Bengzon, Johan
    JOURNAL OF NEURO-ONCOLOGY, 2017, 131 (02) : 245 - 254
  • [44] Paclitaxel-releasing mesenchymal stromal cells inhibit in vitro proliferation of human mesothelioma cells
    Petrella, Francesco
    Cocce, Valentina
    Masia, Carla
    Milani, Martina
    Sale, Emanuela Omodeo
    Alessandri, Giulio
    Parati, Eugenio
    Sisto, Francesca
    Pentimalli, Francesca
    Brini, Anna T.
    Pessina, Augusto
    Spaggiari, Lorenzo
    BIOMEDICINE & PHARMACOTHERAPY, 2017, 87 : 755 - 758
  • [45] Increased in vivo angiogenic effect of glioma stromal mesenchymal stem-like cells on glioma cancer stem cells from patients with glioblastoma
    Kong, Byung Ho
    Shin, Hyun-Do
    Kim, Se-Hoon
    Mok, Hyun-Su
    Shim, Jin-Kyoung
    Lee, Ji-Hyun
    Shin, Hye-Jin
    Huh, Yong-Min
    Kim, Eui-Hyun
    Park, Eun-Kyung
    Chang, Jong Hee
    Kim, Dong-Seok
    Hong, Yong-Kil
    Kim, Sun Ho
    Lee, Su-Jae
    Kang, Seok-Gu
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2013, 42 (05) : 1754 - 1762
  • [46] In vitro cultivation of canine multipotent mesenchymal stromal cells on collagen membranes treated with hyaluronic acid for cell therapy and tissue regeneration
    Wodewotzky, T. I.
    Lima-Neto, J. F.
    Pereira-Junior, O. C. M.
    Sudano, M. J.
    Lima, S. A. F.
    Bersano, P. R. O.
    Yoshioka, S. A.
    Landim-Alvarenga, F. C.
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2012, 45 (12) : 1157 - 1162
  • [47] Mesenchymal Stromal Cells Derived from Canine Adipose Tissue: Evaluation of the Effect of Different Shipping Vehicles Used for Clinical Administration
    Andreoli, Valentina
    Berni, Priscilla
    Conti, Virna
    Ramoni, Roberto
    Basini, Giuseppina
    Grolli, Stefano
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (06)
  • [48] Isolation and characterization of canine placenta-derived mesenchymal stromal cells for the treatment of neurological disorders in dogs
    Long, Connor
    Lankford, Lee
    Kumar, Priyadarsini
    Grahn, Robert
    Borjesson, Dori L.
    Farmer, Diana
    Wang, Aijun
    CYTOMETRY PART A, 2018, 93A (01) : 82 - 92
  • [49] Modular Orthopaedic Tissue Engineering With Implantable Microcarriers and Canine Adipose-Derived Mesenchymal Stromal Cells
    Simitzi, Chara
    Vlahovic, Maja
    Georgiou, Alex
    Keskin-Erdogan, Zalike
    Miller, Joanna
    Day, Richard M.
    FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020, 8
  • [50] Characterization of canine adipose- and endometrium-derived Mesenchymal Stem/Stromal Cells and response to lipopolysaccharide
    Phyo, Hlaing
    Aburza, Amira
    Mellanby, Katie
    Esteves, Cristina L. L.
    FRONTIERS IN VETERINARY SCIENCE, 2023, 10
12345