Effect of canine mesenchymal stromal cells loaded with paclitaxel on growth of canine glioma and human glioblastoma cell lines

被引：18
|
作者：
Bonomi, A. [1 ]
Ghezzi, E. [2 ]
Pascucci, L. [3 ]
Aralla, M. [2 ]
Ceserani, V. [4 ]
Pettinari, L. [2 ]
Cocce, V. [1 ]
Guercio, A. [5 ]
Alessandri, G. [4 ]
Parati, E. [4 ]
Brini, A. T. [1 ,6 ]
Zeira, O. [2 ]
Pessina, A. [1 ]
机构：
[1] Univ Milan, Dept Biomed Surg & Dent Sci, Via Pascal 36, I-20133 Milan, Italy
[2] Vet Hosp San Michele, Via 1 Maggio 37, I-26838 Lodi, Italy
[3] Univ Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, Italy
[4] IRCCS, Neurol Inst C Besta, Cellular Neurobiol Lab, Dept Cerebrovasc Dis, Via Celoria 11, I-20133 Milan, Italy
[5] Ist Zooprofilatt Sperimentale Sicilia A Mirri, Area Diagnost Virol, Palermo, Italy
[6] IRCCS, Galeazzi Orthopaed Inst, Milan, Italy
来源：
VETERINARY JOURNAL | 2017年 / 223卷
关键词：
Canine; Drug delivery; Glioma; Mesenchymal stromal cells; Paclitaxel; STEM-CELLS; IN-VITRO; ADIPOSE-TISSUE; EFFICACY; DELIVERY; VEHICLES; TUMORS;
D O I：
10.1016/j.tvjl.2017.05.005
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
This study investigated whether canine mesenchymal stromal cells (cMSCs) are able to take up and release paclitaxel (PTX) in active form, and therefore whether they have potential as a tool for therapeutic delivery of this drug. cMSCs from bone marrow and adipose tissue were isolated, expanded and characterised phenotypically. cMSCs were loaded with PTX (cMSCs-PTX) and their capacity for release of PTX was determined by their effect on proliferation of cancer cells. cMSCs-PTX derived from bone marrow and adipose tissue were able to take up and then release active PTX. cMSCs-PTC inhibited proliferation of the canine glioma cell line J3T, and the human glioblastoma cell lines T98G and U87MG. The potential of canine cMSCs-PTX for treatment of canine gliomas should be investigated further. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：45 / 51
页数：7
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