Structure Evolution of Curcumin Nanoprecipitation from a Micromixer

被引：52

作者：

He, Yi ^{[1
]}

Huang, Yanbin ^{[1
]}

Cheng, Yi ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem Engn, Beijing 100084, Peoples R China

来源：

CRYSTAL GROWTH & DESIGN | 2010年 / 10卷 / 03期

基金：

中国国家自然科学基金;

关键词：

PRECIPITATION; NANOPARTICLES;

D O I：

10.1021/cg9009916

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Drug nanocrystal has become an important technology for poorly water-soluble drug delivery,and it is highly desirable to understand their formation mechanism and structure evolution pathway. Here we used curcumin as the model drug and studied in detail its nanoprecipitate structure evolution from a micromixer. Curcumin initially precipitated out as amorphous nanospheres, and then went through amorphous aggregation before transforming into needle-shaped crystals. The results clearly show a nonclassical crystallization pathway for curcumin nanoprecipitation.

引用

页码：1021 / 1024

页数：4

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