Monoclonal Antibodies for Multiple Sclerosis Treatment

被引:1
|
作者
Palavra, Filipe [1 ,2 ]
机构
[1] Univ Coimbra, Fac Med, Inst Biomed Imaging & Life Sci, CNC,IBILI Res Unit, Coimbra, Portugal
[2] Univ Coimbra, Fac Med, Inst Nucl Sci Appl Hlth ICNAS, Coimbra, Portugal
来源
ACTA MEDICA PORTUGUESA | 2015年 / 28卷 / 05期
关键词
Antibodies; Monoclonal; Clinical Trials; Multiple Sclerosis; HIGH-YIELD PROCESS; DOUBLE-BLIND; DISEASE-ACTIVITY; ENDOGENOUS RETROVIRUS; NATALIZUMAB; DACLIZUMAB; ALEMTUZUMAB; MULTICENTER; THERAPY; CELLS;
D O I
10.20344/amp.6486
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Since their introduction in medical therapy, in the last quarter of the 20th century, monoclonal antibodies have gained an increasing importance in the treatment of various diseases. Neurology has been one of the medical specialties benefiting of the therapeutic potential of these monoclonal antibodies and certain neurological conditions may now contain such drugs in their therapeutic algorithms. Multiple sclerosis is one of these diseases and, in addition to the monoclonal antibodies already licensed for clinical use, several others are in development for future utilization in this specific area. The future will certainly pass through this kind of drugs and, in this article, a review of the most relevant data related to monoclonal antibodies already in use and also in clinical development for multiple sclerosis treatment will be performed.
引用
收藏
页码:640 / 651
页数:12
相关论文
共 50 条
  • [1] Monoclonal Antibodies in the Treatment of Multiple Sclerosis
    Di Pauli, F.
    Berger, T.
    Reindl, M.
    CURRENT MEDICINAL CHEMISTRY, 2009, 16 (36) : 4858 - 4868
  • [2] Monoclonal antibodies in treatment of multiple sclerosis
    Rommer, P. S.
    Dudesek, A.
    Stueve, O.
    Zettl, U. K.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2014, 175 (03) : 373 - 384
  • [3] Safety of monoclonal antibodies for the treatment of multiple sclerosis
    McGinley, Marisa P.
    Moss, Brandon P.
    Cohen, Jeffrey A.
    EXPERT OPINION ON DRUG SAFETY, 2017, 16 (01) : 89 - 100
  • [4] Parenteral Treatment of Multiple Sclerosis: The Advent of Monoclonal Antibodies
    Singer, Barry A.
    SEMINARS IN NEUROLOGY, 2016, 36 (02) : 140 - 147
  • [5] Monoclonal Antibodies in Multiple Sclerosis: Present and Future
    Voge, Natalia V.
    Alvarez, Enrique
    BIOMEDICINES, 2019, 7 (01)
  • [6] Monoclonal antibodies in the development of multiple sclerosis
    Sastre-Garriga, J.
    Montalban, X.
    NEUROLOGIA, 2011, 26 (09): : 556 - 562
  • [7] Survey of Latin American Neuroimmunologists on the Treatment of Multiple Sclerosis with Monoclonal Antibodies
    Fragoso, Yara Dadalti
    CURRENT DRUG SAFETY, 2015, 10 (03) : 217 - 220
  • [8] Monoclonal antibodies in the therapy of multiple sclerosis An overview
    Rommer, P. S.
    Stueve, O.
    Goertsches, R.
    Mix, E.
    Zettl, U. K.
    JOURNAL OF NEUROLOGY, 2008, 255 (Suppl 6) : 28 - 35
  • [9] Novel monoclonal antibodies for therapy of multiple sclerosis
    Knier, Benjamin
    Hemmer, Bernhard
    Korn, Thomas
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2014, 14 (04) : 503 - 513
  • [10] Therapeutic Monoclonal Antibodies and Multiple Sclerosis: The Essentials
    Heliopoulos, Ioannis
    Patousi, Athanasia
    MEDICINAL CHEMISTRY, 2018, 14 (02) : 144 - 154