Notch Signaling in the Immune System

被引：486

作者：

Radtke, Freddy ^{[1
]}

Fasnacht, Nicolas ^{[1
]}

MacDonald, H. Robson ^{[2
]}

机构：

[1] Ecole Polytech Fed Lausanne, Swiss Inst Expt Canc Res, CH-1015 Lausanne, Switzerland

[2] Univ Lausanne, Lausanne Branch, Ludwig Inst Canc Res, CH-1066 Epalinges, Switzerland

来源：

IMMUNITY | 2010年 / 32卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

HEMATOPOIETIC STEM-CELLS; ACUTE LYMPHOBLASTIC-LEUKEMIA; GAMMA-SECRETASE INHIBITORS; REGULATORY T-CELLS; NF-KAPPA-B; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; DELTA-LIKE; IN-VIVO; DENDRITIC CELLS; LINEAGE COMMITMENT;

D O I：

10.1016/j.immuni.2010.01.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Notch signaling pathway regulates many aspects of embryonic development, as well as differentiation processes and tissue homeostasis in multiple adult organ systems. Disregulation of Notch signaling is associated with several human disorders, including cancer. In the last decade, it became evident that Notch signaling plays important roles within the hematopoietic and immune systems. Notch plays an essential role in the development of embryonic hematopoietic stem cells and influences multiple lineage decisions of developing lymphoid and myeloid cells. Moreover, recent evidence suggests that Notch is an important modulator of T cell-mediated immune responses. In this review, we discuss Notch signaling in hematopoiesis, lymphocyte development, and function as well as in T cell acute lymphoblastic leukemia.

引用

页码：14 / 27

页数：14

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